917605
2-(4-(Piperidin-4-yl)phenyl)acetic acid hydrochloride
≥95%
Manufacturer: Sigma Aldrich
CAS Number: 34033-52-8
Synonym(S): Semi-flexible linker for PROTAC® development
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | 917605-100-MG | In Stock | ₹ 26,499.60 |
917605 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 26,499.60
GST (18%): ₹ 4,769.928
Total Price: ₹ 31,269.528
Quality Level
100
Assay
≥95%
form
powder
reaction suitability
reagent type: linker
functional group
carboxylic acid
storage temp.
2-8°C
SMILES string
O=C(CC(C=C1)=CC=C1C2CCNCC2)O.Cl
Related Products
Description
- Application: 2-(4-(Piperidin-4-yl)phenyl)acetic acid hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
- Other Notes: Portal: Building PROTAC® Degraders for Targeted Protein DegradationCrosslinkers for BioconjugationTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Quality Level: 100
Assay: ≥95%
form: powder
reaction suitability: reagent type: linker
functional group: carboxylic acid
storage temp.: 2-8°C
SMILES string: O=C(CC(C=C1)=CC=C1C2CCNCC2)O.Cl
Quality Level:
100
Assay:
≥95%
form:
powder
reaction suitability:
reagent type: linker
functional group:
carboxylic acid
storage temp.:
2-8°C
SMILES string:
O=C(CC(C=C1)=CC=C1C2CCNCC2)O.Cl
Quality Level: 100
Assay: __
form: powder
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: C[C@H](NCCCCCCCCCCN)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCC)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O.Cl
Quality Level:
100
Assay:
__
form:
powder
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
C[C@H](NCCCCCCCCCCN)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCC)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O.Cl
Quality Level: 100
Assay: __
form: powder
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCCOCCOCCOCCN)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O.Cl
Quality Level:
100
Assay:
__
form:
powder
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCCOCCOCCOCCN)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O.Cl
Quality Level: 100
Assay: ≥85%
form: powder
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCCCCCCCCCCN)=O)CC2=CC=C(C=C2)F)=O)=O)C3CCCCC3)=O
Quality Level:
100
Assay:
≥85%
form:
powder
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCCCCCCCCCCN)=O)CC2=CC=C(C=C2)F)=O)=O)C3CCCCC3)=O