920738
Pomalidomide-C9-NH2 hydrochloride
Manufacturer: Sigma Aldrich
CAS Number: 2305936-77-8
Synonym(S): 4-((9-Aminononyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride, Crosslinker-E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 920738-50-MG | In Stock | ₹ 59,721.53 |
920738 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 59,721.53
GST (18%): ₹ 10,749.875
Total Price: ₹ 70,471.405
ligand
pomalidomide
Quality Level
100
form
crystals
reaction suitability
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group
amine
storage temp.
−20°C
SMILES string
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCCCCCCCCN)=O)NC1=O.Cl
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | 2305936-77-8 | Thalidomide-NH-C9-NH2 hydrochloride | A2B Chem | ₹ 35,079.60 - ₹ 54,330.60 |
Related Products
Description
- Application: Protein degrader builiding block Pomalidomide-C9-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.This conjugate contains a Cereblon (CRBN)-recruiting ligand, a rigid linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
- Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC® Degraders for Targeted Protein DegradationTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 1B
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
ligand: pomalidomide
Quality Level: 100
form: crystals
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: −20°C
SMILES string: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCCCCCCCCN)=O)NC1=O.Cl
ligand:
pomalidomide
Quality Level:
100
form:
crystals
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
−20°C
SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCCCCCCCCN)=O)NC1=O.Cl
ligand: pomalidomide
Quality Level: 100
form: solid
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: O=C(N(C1CCC(NC1=O)=O)C2=O)C3=C2C=CC=C3NC(C4=CC=C(CN5CCNCC5)C=C4)=O.Cl
ligand:
pomalidomide
Quality Level:
100
form:
solid
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
O=C(N(C1CCC(NC1=O)=O)C2=O)C3=C2C=CC=C3NC(C4=CC=C(CN5CCNCC5)C=C4)=O.Cl
ligand: C5 Lenalidomide
Quality Level: 100
form: solid
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(C4=CC=C(CN5CCNCC5)C=C4)=O)=CC=C31.Cl
ligand:
C5 Lenalidomide
Quality Level:
100
form:
solid
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(C4=CC=C(CN5CCNCC5)C=C4)=O)=CC=C31.Cl
ligand: VH032
Quality Level: 100
form: solid
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(C4=CC=C(CN5CC[ClH](CC5)=N)C=C4)=O)C(C)(C)C)=O)=O)C=C2
ligand:
VH032
Quality Level:
100
form:
solid
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(C4=CC=C(CN5CC[ClH](CC5)=N)C=C4)=O)C(C)(C)C)=O)=O)C=C2