920908
(S,R,S)-VL285 Phenol
Manufacturer: Sigma Aldrich
CAS Number: 1448188-69-9
Synonym(S): (2S,4R)-4-Hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide, VHL E3 ligase ligand for PROTAC® research
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | 920908-100-MG | In Stock | ₹ 49,780.00 |
920908 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 49,780.00
GST (18%): ₹ 8,960.40
Total Price: ₹ 58,740.40
ligand
VL285 phenol
Quality Level
100
form
solid
reaction suitability
reagent type: ligand
functional group
amine
storage temp.
2-8°C
SMILES string
O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)C)N2CC(C=CC=C3)=C3C2=O)=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4O
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | eMolecules Medchem Express / VL285 Phenol / 5mg / 788478474 / HY-151227 / / 1448188-69-9 / [null] / 548.660 / C29H32N4O5S | eMolecules | ₹ 11,334.99 |
Related Products
Description
- Application: (S,R,S)-VL285 Phenol is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology, providing an alternative to the widely used VH032 (901490).(S,R,S)-VL285 Phenol-linker conjugates are also available for synthesis of degraders. Browse our full offering of degrader building blocks that streamlines the synthesis of degrader libraries.
- Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationHaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion ProteinsSystematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degradersDesign, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic propertiesDifferential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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ligand: VL285 phenol
Quality Level: 100
form: solid
reaction suitability: reagent type: ligand
functional group: amine
storage temp.: 2-8°C
SMILES string: O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)C)N2CC(C=CC=C3)=C3C2=O)=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4O
ligand:
VL285 phenol
Quality Level:
100
form:
solid
reaction suitability:
reagent type: ligand
functional group:
amine
storage temp.:
2-8°C
SMILES string:
O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)C)N2CC(C=CC=C3)=C3C2=O)=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4O
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Quality Level: 300
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