QBD10852

dPEG®12-SATA (S-acetyl-dPEG®12-NHS ester)

Manufacturer: Sigma Aldrich

CAS Number: 1334169-95-7

Synonym(S): alpha-[2-(acetylthio)ethyl]-omega-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy]poly(oxy-1,2-ethanediyl)

Select a Size

Pack Size SKU Availability Price
100 MG QBD10852-100-MG In Stock ₹ 51,927.53
1000 MG QBD10852-1000-MG In Stock ₹ 1,46,234.93

QBD10852 - 100 MG

₹ 51,927.53

In Stock

Quantity

1

Base Price: ₹ 51,927.53

GST (18%): ₹ 9,346.955

Total Price: ₹ 61,274.485

Assay

>90%

form

solid or viscous liquid

reaction suitability

reagent type: chemical modification reagentreagent type: cross-linking reagentreactivity: amine reactive

polymer architecture

shape: linearfunctionality: monofunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCSC(C)=O)ON1C(CCC1=O)=O

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Description

  • Features and Benefits: dPEG®12-SATA (S-acetyl-dPEG®12-NHS ester) contains an acetyl-protected thiol on one end of a single molecular weight dPEG® linker and an amine-reactive N-hydroxysuccinimide (NHS) ester on the other end. One or more free primary amines on the target molecule can be reacted with dPEG®12-SATA to install a protected thiol connected to the molecule via the dPEG® linker. Three different linker lengths provide precise distance control between the target molecule and the acetyl-protected thiol group. The dPEG® linker imparts water solubility and reduced immunogenicity to the target molecule. Compared to reagents containing only hydrocarbon spacers, dPEG®-containing reagents also reduce aggregation and precipitation of crosslinked proteins. The acetyl group is easily removed by mild chemical deprotection with hydroxylamine hydrochloride, exposing the free thiol, which can then be used to form a disulfide or thiol ether bond to another molecule. Although commonly used with proteins, these reagents are also suitable for any small molecules or peptides with suitable functionalities.
  • Legal Information: Products Protected under U.S. Patents # 7,888,536 B2

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Assay:
>90%

form:
solid or viscous liquid

reaction suitability:
reagent type: chemical modification reagentreagent type: cross-linking reagentreactivity: amine reactive

polymer architecture:
shape: linearfunctionality: monofunctional

shipped in:
ambient

storage temp.:
−20°C

SMILES string:
O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCSC(C)=O)ON1C(CCC1=O)=O

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>90%

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solid or viscous liquid

reaction suitability:
reagent type: cross-linking reagentreactivity: carboxyl reactive

polymer architecture:
shape: linearfunctionality: heterobifunctional

shipped in:
ambient

storage temp.:
−20°C

SMILES string:
NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O

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SMILES string:
O=C(OC1=C(C(F)=C(C(F)=C1F)F)F)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(OC2=C(C(F)=C(C(F)=C2F)F)F)=O

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ambient

storage temp.:
−20°C

SMILES string:
O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O