472611

(1,3-Dioxolan-2-ylmethyl)magnesium bromide solution

0.5 M in THF

Manufacturer: Sigma Aldrich

CAS Number: 180675-22-3

Synonym(S): 2-[(Bromomagnesio)methyl]-1,3-dioxolane, Bromo(1,3-dioxolan-2-ylmethyl)magnesium

Select a Size

Pack Size SKU Availability Price
100 ML 472611-100-ML In Stock ₹ 13,325.58
1 L 472611-1-L In Stock ₹ 52,403.83

472611 - 100 ML

₹ 13,325.58

In Stock

Quantity

1

Base Price: ₹ 13,325.58

GST (18%): ₹ 2,398.604

Total Price: ₹ 15,724.184

reaction suitability

reaction type: Grignard Reaction

Quality Level

100

concentration

0.5 M in THF

bp

65-67 °C

density

0.938 g/mL at 25 °C

SMILES string

Br[Mg]CC1OCCO1

InChI

1S/C4H7O2.BrH.Mg/c1-4-5-2-3-6-4;;/h4H,1-3H2;1H;/q;;+1/p-1

InChI key

ZDNTZRAFJZERSL-UHFFFAOYSA-M

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Description

  • Application: (1,3-Dioxolan-2-ylmethyl)magnesium bromide is a Grignard reagent that can be used to prepare:3-[11C]-Propionaldehyde, a key intermediate for the synthesis of radiolabeled compound [11C]SN-38, wherein SN-38 is 7-ethyl-10-hydroxy camptothecin.[1]1-[(S)-2,2-Dimethyl-(1,3)-dioxolan-4-yl]-4-(1,3-dioxolan2-yl)-2-ol by reacting with D-glyceraldehyde, which is further used to synthesize unsaturated nucleosides.[2]A bicyclo carboxylate intermediate, which is employed in the total synthesis of spirovibsanin A.[3]

SAFETY INFORMATION

Pictograms

GHS02,GHS08,GHS05,GHS07

Signal Word

Danger

Hazard Statements

H225,H302,H314,H335,H336,H351

Precautionary Statements

P201 - P210 - P280 - P303 + P361 + P353 - P305 + P351 + P338 + P310 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3

Target Organs

Central nervous system, Respiratory system

Supplementary Hazards

EUH018,EUH019

WGK

WGK 3

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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reaction suitability:
reaction type: Grignard Reaction

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100

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density:
0.938 g/mL at 25 °C

SMILES string:
Br[Mg]CC1OCCO1

InChI:
1S/C4H7O2.BrH.Mg/c1-4-5-2-3-6-4;;/h4H,1-3H2;1H;/q;;+1/p-1

InChI key:
ZDNTZRAFJZERSL-UHFFFAOYSA-M

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