35-655-0

Tocris Bioscience™ ONO AE3 208

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 35-655-0-Each-of-1 In Stock ₹ 1,19,441.76

35-655-0 - Each of 1

₹ 1,19,441.76

In Stock

Quantity

1

Base Price: ₹ 1,19,441.76

GST (18%): ₹ 21,499.517

Total Price: ₹ 1,40,941.277

Purity

>98%

Product Type

ONO AE3 208

Inhibitors

ONO AE3 208

Quantity

50 mg

Molecular Weight (g/mol)

404.43

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Description

  • High affinity and selective EP4 receptor antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively)
  • Displays no affinity for EP1, EP2, DP or IP receptors (Ki >10 μM)
  • Inhibits PGE2-induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE2 inhibition of natural killer T cell activation
  • Suppresses recovery from experimentally-induced colitis and stimulates CD4+ T cell proliferation in C57BL/6 mice
  • Also reduces metastasis of mammary tumor cells in a murine model of breast cancer
  • Orally active.

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