5545945
Tocris Bioscience™ ONO AE3 208
High affinity and selective EP4 antagonist
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
ONO AE3 208
Molecular Weight (g/mol)
404.43
Inhibitors
ONO AE3 208
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Description
- High affinity and selective EP4 receptor antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively)
- Displays no affinity for EP1, EP2, DP or IP receptors (Ki >10 μM)
- Inhibits PGE2-induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE2 inhibition of natural killer T cell activation
- Suppresses recovery from experimentally-induced colitis and stimulates CD4+ T cell proliferation in C57BL/6 mice
- Also reduces metastasis of mammary tumor cells in a murine model of breast cancer
- Orally active.
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Purity: >98%
Product Type: ONO AE3 208
Molecular Weight (g/mol): 404.43
Inhibitors: ONO AE3 208
Purity:
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Molecular Weight (g/mol):
404.43
Inhibitors:
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Purity: >98%
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Molecular Weight (g/mol): 295.33
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Purity:
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Molecular Weight (g/mol): 445.44
Inhibitors: Paroxetine maleate
Purity:
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Product Type:
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Purity: >98%
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Molecular Weight (g/mol): 362.34
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Purity:
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Molecular Weight (g/mol):
362.34
Inhibitors:
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