45-981-0

Tocris Bioscience™ PHT 427

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

>98%

Product Type

PHT 427

Inhibitors

PHT 427

Quantity

10 mg

Molecular Weight (g/mol)

409.61

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Description

  • Dual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2 μM, respectively)
  • Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro
  • Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.

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