47-011-0
Tocris Bioscience™ EC 144
Manufacturer: Tocris Bioscience™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 47-011-0-Each-of-1 | In Stock | ₹ 33,759.48 |
47-011-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 33,759.48
GST (18%): ₹ 6,076.706
Total Price: ₹ 39,836.186
Purity
>98%
Product Type
EC 144
Inhibitors
EC 144
Quantity
10 mg
Molecular Weight (g/mol)
413.9
Related Products
Description
- EC 144 is a high affinity, potent and selective Hsp90 inhibitor (Ki = 0.2 nM and IC50 = 1.1 nM)
- Exhibits selectivity for Hsp90 over Grp94 and TRAP1 (Ki values are 61 and 255 nM respectively) and has no effect (IC50 >10 μM) against a panel of 285 kinases
- Degrades Her-2 in MCF-7 breast cancer cells (EC50 = 14 nM)
- Blocks tumor growth and induces partial tumor regression in an N87 gastric tumor mouse model
- Also inhibits LPS-induced TNFα release in an LPS shock mouse model and suppresses disease development in a rat model of collagen-induced arthritis
- Exhibits <20-fold efficacy over BIIB 021 (Cat
- No
- 4608) in mice
- Orally available and brain penetrant.
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