49-311-0

Tocris Bioscience™ EG 00229

Manufacturer: Tocris Bioscience™

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Purity

>98%

Product Type

EG 00229

Inhibitors

EG 00229

Quantity

10 mg

Molecular Weight (g/mol)

497.57

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Description

  • Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to the NRP1 b1 domain
  • Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2
  • Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs
  • Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro
  • Increases chemo-sensitivity of A549 cells in combination with Taxol (Cat
  • No
  • 1097)
  • Blocks pro-tumorigenic M2 polarization in glioma-associated microglia and macrophages and reduces tumor growth and vascularization in NSG mice.

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