51-901-0
Tocris Bioscience™ FRAX 486
Manufacturer: Tocris Bioscience™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 51-901-0-Each-of-1 | In Stock | ₹ 27,978.12 |
51-901-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 27,978.12
GST (18%): ₹ 5,036.062
Total Price: ₹ 33,014.182
Purity
>98%
Product Type
FRAX 486
Inhibitors
FRAX 486
Quantity
10 mg
Molecular Weight (g/mol)
513.39
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Description
- FRAX 486 is a potent p21-activated kinase (PAK) inhibitor (IC50 values are 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively)
- Blocks and reverses the DISC1 knockdown-induced reduction in dendritic spine size in cortical neurons
- Attenuates dendritic spine elimination and enhances spine generation in DISC1 knockdown mice
- Ameliorates autism-like behavioral symptoms in fragile X mental retardation 1 (Fmr1) knockout mice
- Brain penetrant and orally bioavailable.
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