5545726

Tocris Bioscience™ BVT 948

Non-competitive protein tyrosine phosphatase inhibitor

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

>98%

Product Type

BVT 948

Molecular Weight (g/mol)

241.25

Inhibitors

BVT 948

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Description

  • Non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP
  • Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo
  • Also inhibits several cytochrome P450 isoforms (IC50 <10 μM).

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