5546080
Tocris Bioscience™ Topiramate
GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV
Manufacturer: Fischer Scientific
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Purity
>99%
Product Type
Topiramate
Inhibitors
Topiramate
Gene Alias
Topamax
Molecular Weight (g/mol)
339.36
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Description
- Anticonvulsant
- Antagonizes GluK1 (formerly GluR5) kainate receptors (IC50 = 0.46 μM), acts as a positive allosteric modulator of GABAA receptor-mediated currents, inhibits Nav channels (IC50 = 48.9 μM) and inhibits L-type Ca2+ channels
- Also inhibits carbonic anhydrase (CA) (Ki values are 0.1 and 0.2 μM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH
- Deuterated analog also available
- Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions .
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Purity: >99%
Product Type: Topiramate
Inhibitors: Topiramate
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