5546181
Tocris Bioscience™ R 268712
Potent and selective inhibitor of TGF-βRI
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
R 268712
Molecular Weight (g/mol)
363.39
Inhibitors
R 268712
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Description
- Potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 = 2.5 nM)
- Exhibits ∽5000-fold selectivity over p38 MAPK
- Suppresses development of renal fibrosis in a unilateral ureteral obstruction model
- Also reduces proteinuria, glomerulosclerosis and improves renal function in an anti-Thy1 glomerulonephritis model
- Orally bioavailable.
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Purity: >98%
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