5546199

Tocris Bioscience™ TC-S 7006

Potent and selective Tpl2 (Cot; MAP3K8) inhibitor

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

>99%

Product Type

TC-S 7006

Molecular Weight (g/mol)

404.83

Inhibitors

TC-S 7006

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Description

  • Potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 50 nM)
  • Selective for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR
  • Inhibits LPS-induced TNF-α secretion from monocytes and attenuates acute myeloid leukemia (AML) cell proliferation in vitro
  • Also reduces cytolytic activity of human CD8+ cytotoxic T lymphocytes
  • Cell permeable.

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