Description

• General description: This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.2-Phenoxyethanol is a commonly used large spectrum-antimicrobial preservative used in cosmetic products and topical pharmaceutical preparations in the concentration range of 0.5–1.0%. It acts by inhibiting the coupling between the electron transport and phosphorylation reactions in mitochondria and disrupting ATP synthesis. It also prevents the activity of malate dehydrogenase and increases the permeability of cell membranes to potassium ions.
• Application: The pharmaceutical secondary standard can also be used as follows:To determine phenoxyethanol and its major metabolite, phenoxyacetic acid by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in rat plasma, urine, and 7 different tissue samplesDevelopment of a reverse phase ultra-high-performance liquid chromatographic (RP-UHPLC) method to quantify 2-phenoxyethanol from commercially available human vaccinesScreening of cosmetic products (CPs) for 17 widely used preservatives by high-performance liquid chromatography-photodiode-array-electrospray ionization-mass spectrometry (HPLC-PDA-ESI/MS)Thin layer chromatography (TLC)-densitometric determination of hydrocortisone acetate and 2-phenoxyethanol in cream samples[1]Analysis of eight volatile and semi-volatile ingredients in a topical formulation by gas chromatography (GC) coupled with a programmed temperature vaporizing (PTV) inlet and a flame ionization detector
• Analysis Note: These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
• Footnote: To see an example of a Certificate of Analysis for this material enter LRAC2814 in the slot below. This is an example certificate only and may not be the lot that you receive.
• Recommended products: Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.