Thermo Scientific™ IMAGEN™ Chlamydia Kit using Direct Immunofluorescence Assay

Description

• The IMAGEN™ Chlamydia test is a qualitative direct immunofluorescence test for the detection of Chlamydia in human uro-genital and ophthalmic specimens and for the confirmation of Chlamydiae in cell culture
• Chlamydia trachomatis has been recognized as a frequent cause of sexually transmitted diseases 1,2 and has been shown to cause a variety of human infections, some of which may be asymptomatic
• Use IMAGEN Chlamydia Direct Kit as a rapid, sensitive and specific method for direct detection and identification of Chlamydiae in clinical specimens or cell cultures
• Rapid results—within little over 30 minutes of receiving test sample or culture Simple—ready-to-use reagents plus all IMAGEN assays follow the same basic methodology Excellent sensitivity and specificity—high quality, well characterized antibodies used in the assay provide excellent sensitivity and specificity Easy-to-read results Long shelf life—typically 24 months Chlamydiae are obligate intracellular parasites closely related to Gram-negative bacteria 1
• The genus Chlamydia contains three known species, Chlamydia trachomatis , Chlamydia psittaci and Chlamydia pneumoniae
• The life cycle of Chlamydiae is complex but two main structures are recognized, the infectious elementary body and the reticulate body
• Currently, there are three main diagnostic methods used for the detection of Chlamydia in clinical specimens
• Firstly, by isolation of the organism and visualization—viable elementary bodies present in clinical specimens infect tissue culture cells and the resultant inclusions are detected by staining techniques, e.g., iodine or immunofluorescence
• Secondly, by direct demonstration of Chlamydia in clinical specimens using a fluorescein-labeled monoclonal antibody
• Thirdly, by enzyme immunoassay (e.g., IDEIA™ PCE Chlamydia Kit) to determine the presence of Chlamydia antigen in clinical specimens 3
• Direct immunofluorescence techniques utilising fluorescein-labeled monoclonal antibodies 4,5,6 have been shown to have good correlation when compared to cell culture techniques for the detection of C
• trachomatis
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