Liofilchem™ MTS™ Omadacycline MIC Test Strips

Description

• Description Ready to use No preparation or dilution of antimicrobial agent is required
• Simply place on an inoculated agar plate and incubate
• Testing can be done on request and at short notice Can be crossed for evaluating a critical assay such as the in vitro combination of antibiotics Rapid and Efficient Easy to set up a full range of MIC testing of 6 agents on a large plate takes no more than 5 minutes Solid Medium Growth of organisms on agar better mimics in vitro conditions Easy to visualize hetero-resistant variants in a population and to detect mixed cultures and contamination Inoculum Tolerant, Macro-method: Most AST methods including broth microdilution and automated systems, are done in a micro format using a relatively low inoculum concentration Systems do not mimic the in vitro infection site nor is the inoculum chosen large enough to reflect the heavy colonization of organisms e.g
• in endocarditis and meningitis Accurate detection of clinically significant low-level and hetero-resistance may be compromised MTS™ is a stable gradient technique that is inoculum tolerant i.e
• changes in inoculum do not affect the MIC results for a susceptible strain
• Thus, it can be used in a macro format with heavier inoculum and a richer media to maximize the detection of low-level and hetero-resistance Easy to Handle Package is small and lightweight Required storage space is minimal Unopened package should be stored at -20°C to 8°C until the given expiry date Leftovers from an opened package (valid for 100 strip pack only, as the 10 and 30 strip packs contain individually packed strips) must be stored at 8°C in the airtight tube, containing desiccant, provided in the pack for no more than 7 days Wide MIC Range MIC range of Each MTS™ gradient spans across 15 dilutions fulfilling pharmacokinetic needs, varying susceptibility of many organism groups and covers different MIC breakpoints used in different countries as recommended by various reference or expert groups Easy to Learn: Minimal training is required for clinical microbiology personnel
• No equipment required Easy for New Agents Easily introduced into clinical routines, as it is a stand-alone single reagent, not a panel product New agents are usually rapidly available in the MTS™ format compared to panel AST systems Clinically, new agents are becoming increasingly important to test and consider as alternative therapeutic options due to increasing resistance MIC Equivalent to Reference Values Scientific references and the clinical testing for device approval has validated that MTS™ MIC values are substantially equivalent to reference values from the CLSI agar and broth microdilution methods MIC interpretive criteria from international standards can be directly applied to interpret results Improved MIC Precision Precise MIC value in μg/ mL is read directly from MTS™ MIC values from MTS™ have an inherent precision of 1/2 dilution due to the continuous gradient Provides an exact on-scale MIC value that is not an in between twofold dilution value Flexible Media Choice Can be used with several AST media provided that the medium supports growth of the organism and is defined and standardized for susceptibility testing Can be used as a quality control tool for checking different AST media, brand to brand and batch to batch Robust Technique As a stable gradient technique, MTS™ is relatively tolerant to variations that can be daily encountered in the laboratory e.g
• inoculum variations and technician performance and can still generate good intra- and inter-laboratory reproducibility Quantitative Value Generates quantitative MIC values that are needed to guide therapy selection for the individual patient's choice, dose and regimen Fastidious and Slow Growers Can be used for fastidious organisms e.g
• anaerobes, and other slow growing organisms and incubation can vary from 1 to 5 days Direct Specimen Testing Due to the gradient and method flexibility, MTS™ can be used to directly test positive blood cultures, CSF and sputum from cystic fibrosis patients and bronchial aspirates from VAP patients The extra day saved by testing the specimen directly can have significant impact in therapy management, patient care and hospital cost savings.