200007286
Tocris Bioscience™ XIE62-1004
Inducer of autophagy via interaction of p62 and LC3
Manufacturer: Fischer Scientific
CAS Number: 2421146-32-7
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Chemical Name or Material
2-[[[3,4-Bis(phenylmethoxy)phenyl]methyl]amino]ethanol hydrochloride
Target
p62/SQSTM1
Purity
0.98
CAS
2421146-32-7
Molecular Formula
C23H25NO3.HCl
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ XIE62-1004 | -- | ₹ 67,472.68 | ||
Tocris Bioscience™ XIE62-1004 | -- | ₹ 16,114.34 | ||
2421146-32-7 | 2-((3,4-BIS(BENZYLOXY)BENZYL)AMINO)ETHAN-1-OL HYDROCHLORIDE | -- | ₹ 2,403.00 - ₹ 26,166.00 |
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Description
- XIE62-1004 is an inducer of p62-LC3 interaction
- Binds to the ZZ domain of p62, leading to p62 self-aggregation and interaction with LC3 on autophagosome membranes; facilitates delivery of cargo proteins to the autophagosome for degradation
- Active in vitro and in vivo in a concentration- and time-dependent manner and is specific for wild type p62
- Induces degradation of mutant huntingtin in vitro
- Can also be used in AUTAC protein degradation systems to induce autophagy through p62 self-aggregation and LC3 interaction.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C