200007275
Tocris Bioscience™ AZ1 USP25/28 inhibitor
Selective USP25 and USP28 inhibitor
Manufacturer: Fischer Scientific
CAS Number: 2165322-94-9
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Chemical Name or Material
2-[[[5-Bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]ethanol
Target
USP28
Purity
0.98
CAS
2165322-94-9
Molecular Formula
C17H16BrF4NO2
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ AZ1 USP25/28 inhibitor | -- | ₹ 15,138.90 | ||
Tocris Bioscience™ AZ1 USP25/28 inhibitor | -- | ₹ 63,679.50 | ||
eMolecules Medchem Express / USP25/28 inhibitor AZ1 / 5mg / 495799959 / HY-117370 / / 2165322-94-9 / [null] / 422.218 / C17H16BrF4NO2 | -- | ₹ 10,480.64 | ||
Medchemexpress LLC HY-117370 5mg Medchemexpress, USP25/28 inhibitor AZ1 CAS:2165322-94-9 Purity:>98% | -- | ₹ 7,476.00 | ||
2165322-94-9 | 2-((5-Bromo-2-((4-fluoro-3-(trifluoromethyl)benzyl)oxy)benzyl)amino)ethan-1-ol | -- | ₹ 6,408.00 - ₹ 34,888.00 |
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Description
- AZ1 USP25/28 inhibitor is a selective inhibitor of USP28 (IC50 = 0.6 μM, Kd= 0.2 - 3.7 μM) and USP25 (IC50 = 0.7 μM)
- AZ1 USP25/28 inhibitor exhibits selectivity for USP25 and USP28 over other DUB family members
- The compound dose-dependently reduces c-Myc levels in colon carcinoma cells in vitro and induces cell death (EC50 values are 18 - 20 μM)
- In a mouse Alzheimer's disease model, AZ1 USP25/28 inhibitor reduces amyloid burden, attenuates microglial activation and improves synaptic and cognitive function.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C