200009228
Tocris Bioscience™ Belinostat
Potent pan-HDAC inhibitor
Manufacturer: Fischer Scientific
CAS Number: 866323-14-0
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Chemical Name or Material
(2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide
Target
Histone Deacetylase Inhibitors
Purity
98%
CAS
866323-14-0
Molecular Formula
C15H14N2O4S
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ Belinostat | Fischer Scientific | ₹ 7,229.82 | |
| | Tocris Bioscience™ Belinostat | Fischer Scientific | ₹ 30,673.26 | |
 | Medchemexpress LLC HY-10225 200mg , Belinostat CAS:866323-14-0 Purity:>98% | Medchemexpress LLC | ₹ 37,731.96 | |
 | eMolecules N-HYDROXY-3-(3-PHENYLSULFAMOYLPHENYL)ACRYLAMIDE | 866323-14-0 | MFCD08064035 | 1g | eMolecules | ₹ 14,357.82 | |
 | 866323-14-0 | Belinostat | A2B Chem | ₹ 3,850.20 - ₹ 1,12,511.40 |
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Description
- Belinostat is a potent pan-HDAC inhibitor (IC50 = 28 nM)
- Dose-dependently reduces tumor volume in a rat model of glioblastoma and induces 70% and 28% apoptosis in LN-229 and LN-18 glioma cell lines (IC50 values are 210 nM and 300 nM respectively)
- In H358 cells, Belinostat dose-dependently reduces cell viability and upregulates amino acids and metabolites of the TCA and urea cycle
- Also potently inhibits C4 release from stem cell-derived astrocytes and shows antidepressant activity
- Belinostat is brain penetrant.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: (2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide
Target: Histone Deacetylase Inhibitors
Purity: 98%
CAS: 866323-14-0
Molecular Formula: C15H14N2O4S
Chemical Name or Material:
(2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide
Target:
Histone Deacetylase Inhibitors
Purity:
98%
CAS:
866323-14-0
Molecular Formula:
C15H14N2O4S
Chemical Name or Material: (S)-2-Amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethylpyrrolo[2,3-b]pyridine-3-carboxamide
Target: Cyclin-dependent Kinase Inhibitors
Purity: 98%
CAS: 2719793-90-3
Molecular Formula: C18H20N4O2
Chemical Name or Material:
(S)-2-Amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethylpyrrolo[2,3-b]pyridine-3-carboxamide
Target:
Cyclin-dependent Kinase Inhibitors
Purity:
98%
CAS:
2719793-90-3
Molecular Formula:
C18H20N4O2
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