200086946
Tocris Bioscience™ MR 24
Potent and selective MST3 kinase binding inhibitor
Manufacturer: Fischer Scientific
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Chemical Name or Material
8-(4-Aminobutyl)-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(1,3-dihydroxypropan-2-ylamino)pyrido[2,3-d]pyrimidin-7-one trihydrochloride
Target
Other Kinase Inhibitors
Molecular Formula
C26H29ClN6O3.3HCl
Purity
0.98
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Description
- MR 24 is a potent and selective MST3 kinase binding inhibitor with >10 fold selectivity over MST4 (EC50 values from NanoBRET assay are 57 nM and 583 nM for MST3 and MST4 respectively)
- MR 24 increases the number of cells in G1 phase of cell cycle, is non-cytotoxic and cell permeable
- Shows 90% stability over 1 hour in activated liver microsomes in vivo .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 8-(4-Aminobutyl)-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(1,3-dihydroxypropan-2-ylamino)pyrido[2,3-d]pyrimidin-7-one trihydrochloride
Target: Other Kinase Inhibitors
Molecular Formula: C26H29ClN6O3.3HCl
Purity: 0.98
Chemical Name or Material:
8-(4-Aminobutyl)-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(1,3-dihydroxypropan-2-ylamino)pyrido[2,3-d]pyrimidin-7-one trihydrochloride
Target:
Other Kinase Inhibitors
Molecular Formula:
C26H29ClN6O3.3HCl
Purity:
0.98
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