71-635-0
Tocris™ Chroman 1
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 71-635-0-Each-of-1 | In Stock | ₹ 1,68,467.64 |
71-635-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,68,467.64
GST (18%): ₹ 30,324.175
Total Price: ₹ 1,98,791.815
Chemical Name or Material
(3 S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1 H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2 H-1-benzopyran-3-carboxamide dihydrochloride
Target
Rho-kinase Inhibitors
Formula Weight
12373
Quantity
50 mg
Molecular Formula
C24H28N4O40.2 HCl
Purity
98%
Related Products
Description
- Chroman 1 is a highly potent and selective ROCK2 (Rho-kinase) inhibitor (IC50 values are 1 and 52 pM at ROCK2 and ROCK1, respectively)
- Chroman 1 exhibits >2000-fold selectivity for ROCK2 over a range of related kinases including MRCK, PKA, and AKT1 (IC50 values are 150, >20000, and >20000 nM, respectively)
- Chroman 1 promotes survival of pluripotent stem cells (PSCs) in culture when used in combination with Emricasan (Cat
- No
- 7310), Polyamines, and Trans-ISRIB (Cat
- No
- 5284), a combination known as CEPT
- When used as part of the CEPT cocktail, Chroman 1 also improves survival of differentiated cells following cryopreservation with cardiomyocyte cell survival increasing by 36% and motor neuron survival improving by 63% compared with DMSO controls.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: (3 S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1 H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2 H-1-benzopyran-3-carboxamide dihydrochloride
Target: Rho-kinase Inhibitors
Formula Weight: 12373
Quantity: 50 mg
Molecular Formula: C24H28N4O40.2 HCl
Purity: 98%
Chemical Name or Material:
(3 S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1 H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2 H-1-benzopyran-3-carboxamide dihydrochloride
Target:
Rho-kinase Inhibitors
Formula Weight:
12373
Quantity:
50 mg
Molecular Formula:
C24H28N4O40.2 HCl
Purity:
98%
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