69-605-0
Tocris™ ABT 199
Manufacturer: Fischer Scientific
CAS Number: 1257044-40-8
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 69-605-0-Each-of-1 | In Stock | ₹ 40,584.00 |
69-605-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,584.00
GST (18%): ₹ 7,305.12
Total Price: ₹ 47,889.12
Chemical Name or Material
4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2 H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1 H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
Synonym
GDC-0199
Target
Bcl-2 Family Inhibitors
Formula Weight
868.45
Purity
98%
CAS
1257044-40-8
Quantity
50 mg
Molecular Formula
C45H50ClN7O7S
Product Type
Inhibitor
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris™ ABT 199 | -- | -- | ||
Tocris™ ABT 199 | -- | ₹ 9,807.80 | ||
Medkoo Biosciences Inc Venetoclax | 1257044-40-8 | MFCD23160052 | 1 g | -- | ₹ 84,016.00 | ||
Enzo Life Sciences Venetoclax (10mg). CAS: 1257044-40-8 | -- | ₹ 15,966.60 | ||
Enzo Life Sciences Venetoclax (200mg). CAS: 1257044-40-8 | -- | ₹ 81,538.24 | ||
Enzo Life Sciences Venetoclax (25mg). CAS: 1257044-40-8 | -- | ₹ 23,233.45 | ||
Enzo Life Sciences Venetoclax (1g). CAS: 1257044-40-8 | -- | ₹ 2,84,130.72 | ||
Enzo Life Sciences Venetoclax (500mg). CAS: 1257044-40-8 | -- | -- | ||
Enzo Life Sciences Venetoclax (300mg). CAS: 1257044-40-8 | -- | ₹ 1,14,233.28 | ||
Medchemexpress LLC Venetoclax | 1257044-40-8 | MFCD23160052 | 10 mM/1 mL in DMSO | -- | ₹ 7,476.00 |
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Description
- ABT 199 is a selective, high affinity Bcl-2 inhibitor (Ki < 0.010 nM)
- Exhibits >4800-fold selectivity for Bcl-2 over Bcl-xL and Bcl-w, and displays no measurable activity at Mcl-1 (Ki > 444 nM)
- Potently induces apoptosis in FL5.12-BCL-2 cells (EC50 = 261 nM) and reduces tumor burden in chronic lymphocytic leukemia (CLL) primary samples (EC50 = 3 nM)
- Shows reduced toxicity to platelets compared to similar compounds
- Enhances efficacy of clinically relevant chemotherapy and immunotherapy drugs
- Orally bioavailable
- Exhibits binding to SARS-CoV-2 3C-like protease (3CLpro) active site in a virtual screen
- ABT 199 reverses oxidative phosphorylation in acute myeloid leukemia cells (AML), in vitro and in vivo .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C