7166834
Tocris™ ABT 199
Selective, high affinity Bcl-2 inhibitor; orally bioavailable
Manufacturer: Fischer Scientific
CAS Number: 1257044-40-8
The price for this product is unavailable. Please request a quote
Chemical Name or Material
4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2 H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1 H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
Synonym
GDC-0199
Molecular Formula
C45H50ClN7O7S
Product Type
Inhibitor
CAS
1257044-40-8
Target
Bcl-2 Family Inhibitors
Formula Weight
868.45
Purity
98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris™ ABT 199 | Fischer Scientific | ₹ 9,428.71 | |
| | Tocris™ ABT 199 | Fischer Scientific | ₹ 39,015.36 | |
 | Medkoo Biosciences Inc Venetoclax | 1257044-40-8 | MFCD23160052 | 1 g | Medkoo Biosciences Inc | ₹ 80,768.64 | |
| | Enzo Life Sciences Venetoclax (10mg). CAS: 1257044-40-8 | Enzo Life Sciences | ₹ 15,349.46 | |
| | Enzo Life Sciences Venetoclax (200mg). CAS: 1257044-40-8 | Enzo Life Sciences | ₹ 78,386.65 | |
| | Enzo Life Sciences Venetoclax (25mg). CAS: 1257044-40-8 | Enzo Life Sciences | ₹ 22,335.44 | |
| | Enzo Life Sciences Venetoclax (1g). CAS: 1257044-40-8 | Enzo Life Sciences | ₹ 2,73,148.59 | |
| | Enzo Life Sciences Venetoclax (500mg). CAS: 1257044-40-8 | Enzo Life Sciences | -- | |
| | Enzo Life Sciences Venetoclax (300mg). CAS: 1257044-40-8 | Enzo Life Sciences | ₹ 1,09,817.97 | |
 | Medchemexpress LLC Venetoclax | 1257044-40-8 | MFCD23160052 | 10 mM/1 mL in DMSO | Medchemexpress LLC | ₹ 7,187.04 |
Related Products
Description
- ABT 199 is a selective, high affinity Bcl-2 inhibitor (Ki < 0.010 nM)
- Exhibits >4800-fold selectivity for Bcl-2 over Bcl-xL and Bcl-w, and displays no measurable activity at Mcl-1 (Ki > 444 nM)
- Potently induces apoptosis in FL5.12-BCL-2 cells (EC50 = 261 nM) and reduces tumor burden in chronic lymphocytic leukemia (CLL) primary samples (EC50 = 3 nM)
- Shows reduced toxicity to platelets compared to similar compounds
- Enhances efficacy of clinically relevant chemotherapy and immunotherapy drugs
- Orally bioavailable
- Exhibits binding to SARS-CoV-2 3C-like protease (3CLpro) active site in a virtual screen
- ABT 199 reverses oxidative phosphorylation in acute myeloid leukemia cells (AML), in vitro and in vivo .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2 H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1 H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
Synonym: GDC-0199
Molecular Formula: C45H50ClN7O7S
Product Type: Inhibitor
CAS: 1257044-40-8
Target: Bcl-2 Family Inhibitors
Formula Weight: 868.45
Purity: 98%
Chemical Name or Material:
4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2 H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1 H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
Synonym:
GDC-0199
Molecular Formula:
C45H50ClN7O7S
Product Type:
Inhibitor
CAS:
1257044-40-8
Target:
Bcl-2 Family Inhibitors
Formula Weight:
868.45
Purity:
98%
Chemical Name or Material: __
Synonym: Capivasertib
Molecular Formula: C21H25ClN6O2
Product Type: Inhibitor
CAS: __
Target: __
Formula Weight: 428.92
Purity: 98%
Chemical Name or Material:
__
Synonym:
Capivasertib
Molecular Formula:
C21H25ClN6O2
Product Type:
Inhibitor
CAS:
__
Target:
__
Formula Weight:
428.92
Purity:
98%
Chemical Name or Material: __
Synonym: __
Molecular Formula: __
Product Type: __
CAS: __
Target: __
Formula Weight: __
Purity: __
Chemical Name or Material:
__
Synonym:
__
Molecular Formula:
__
Product Type:
__
CAS:
__
Target:
__
Formula Weight:
__
Purity:
__
Chemical Name or Material: __
Synonym: __
Molecular Formula: __
Product Type: __
CAS: __
Target: __
Formula Weight: __
Purity: __
Chemical Name or Material:
__
Synonym:
__
Molecular Formula:
__
Product Type:
__
CAS:
__
Target:
__
Formula Weight:
__
Purity:
__