7239460
Tocris Bioscience™ MRTX 849
Mutation-selective inhibitor of KRASG12C
Manufacturer: Fischer Scientific
CAS Number: 2326521-71-3
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Chemical Name or Material
4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile
Target
Ras GTPase Inhibitors
Purity
98%
CAS
2326521-71-3
Molecular Formula
C32H35ClFN7O2
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ MRTX 849 | Fischer Scientific | ₹ 30,288.24 | |
| | Tocris Bioscience™ MRTX 849 | Fischer Scientific | ₹ 1,26,628.80 | |
 | Medchemexpress LLC HY-130149 500mg , Adagrasib CAS:2326521-71-3 Purity:>98% | Medchemexpress LLC | ₹ 1,34,757.00 | |
 | Medchemexpress LLC HY-130149 10mg Medchemexpress, MRTX849 CAS:2326521-71-3 Purity:>98% | Medchemexpress LLC | ₹ 10,331.37 | |
 | Chemie Tek MRTX849 | 2326521-71-3 | MFCD32263433 | 10mg | Chemie Tek | ₹ 8,384.88 | |
| | eMolecules Adagrasib (MRTX849) | 2326521-71-3 | | 5mg | eMolecules | ₹ 30,315.62 | |
 | 2326521-71-3 | 2-Piperazineacetonitrile, 4-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2S)- | A2B Chem | ₹ 3,422.40 - ₹ 1,48,532.16 |
Related Products
Description
- MRTX 849 is a mutant-selective inhibitor of KRASG12C (IC50 = 142 nM)
- MRTX 849 covalently binds to KRASG12C at the cysteine at residue 12 and inhibits KRAS-dependent signal transduction by locking the protein in its inactive GDP-bound state
- MRTX 849 induces pronounced tumor regression in 17 of 26 (65%) KRASG12C -positive cell lines and patient-derived xenograft models from multiple tumor types
- It is orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile
Target: Ras GTPase Inhibitors
Purity: 98%
CAS: 2326521-71-3
Molecular Formula: C32H35ClFN7O2
Chemical Name or Material:
4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile
Target:
Ras GTPase Inhibitors
Purity:
98%
CAS:
2326521-71-3
Molecular Formula:
C32H35ClFN7O2
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