77-135-0
Tocris Bioscience™ AMG 510
Manufacturer: Fischer Scientific
CAS Number: 2252403-56-6
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 77-135-0-Each-of-1 | In Stock | ₹ 82,903.50 |
77-135-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 82,903.50
GST (18%): ₹ 14,922.63
Total Price: ₹ 97,826.13
Chemical Name or Material
(1 R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2 S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1 H)-one
Quantity
50 mg
Molecular Formula
C30H30F2N6O3
CAS
2252403-56-6
Target
Ras GTPase Inhibitors
Purity
0.98
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ AMG 510 | Fischer Scientific | -- | |
| | Tocris Bioscience™ AMG 510 | Fischer Scientific | ₹ 19,847.00 | |
 | Medchemexpress LLC AMG-510 | 2252403-56-6 | MFCD32062763 | 10 mM * 1 mL in DMSO | Medchemexpress LLC | ₹ 10,372.95 | |
 | 2252403-56-6 | Pyrido[2,3-d]pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]- | A2B Chem | ₹ 16,465.00 - ₹ 23,496.00 |
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Description
- AMG 510 is a potent and selective covalent KRASG12C inhibitor (IC50 = 90 nM)
- Also a potent inhibitor of phospho-ERK (IC50 = 68 nM)
- In an in vivo model of non-small cell lung cancer, AMG 510 causes regression of tumors, an increase in T-cell recruitment and a pro-inflammatory tumor microenvironment
- Synergises with MEK inhibitors and Carboplatin (Cat
- No
- 2626) and is orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: (1 R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2 S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1 H)-one
Quantity: 50 mg
Molecular Formula: C30H30F2N6O3
CAS: 2252403-56-6
Target: Ras GTPase Inhibitors
Purity: 0.98
Chemical Name or Material:
(1 R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2 S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1 H)-one
Quantity:
50 mg
Molecular Formula:
C30H30F2N6O3
CAS:
2252403-56-6
Target:
Ras GTPase Inhibitors
Purity:
0.98
Chemical Name or Material: N-(4,4,5,5-Tetradehydro-D-norvalyl)-D-alanine trifluoroacetate
Quantity: 10 mg
Molecular Formula: C8H12N2O3.CF3CO2H
CAS: 87156-01-2
Target: Unnatural Amino Acids
Purity: 0.95
Chemical Name or Material:
N-(4,4,5,5-Tetradehydro-D-norvalyl)-D-alanine trifluoroacetate
Quantity:
10 mg
Molecular Formula:
C8H12N2O3.CF3CO2H
CAS:
87156-01-2
Target:
Unnatural Amino Acids
Purity:
0.95
Chemical Name or Material: 3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
Quantity: 10 mg
Molecular Formula: C26H31N7O
CAS: 1358099-18-9
Target: Ubiquitin Ligase (E3) Inhibitors
Purity: __
Chemical Name or Material:
3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
Quantity:
10 mg
Molecular Formula:
C26H31N7O
CAS:
1358099-18-9
Target:
Ubiquitin Ligase (E3) Inhibitors
Purity:
__
Chemical Name or Material: 3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
Quantity: 50 mg
Molecular Formula: C26H31N7O
CAS: 1358099-18-9
Target: Ubiquitin Ligase (E3) Inhibitors
Purity: __
Chemical Name or Material:
3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
Quantity:
50 mg
Molecular Formula:
C26H31N7O
CAS:
1358099-18-9
Target:
Ubiquitin Ligase (E3) Inhibitors
Purity:
__