74-881-0

Tocris Bioscience™ MRTX 849

Manufacturer: Fischer Scientific

CAS Number: 2326521-71-3

Select a Size

Pack Size SKU Availability Price
Each of 1 74-881-0-Each-of-1 In Stock ₹ 30,288.24

74-881-0 - Each of 1

₹ 30,288.24

In Stock

Quantity

1

Base Price: ₹ 30,288.24

GST (18%): ₹ 5,451.883

Total Price: ₹ 35,740.123

Chemical Name or Material

4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile

Quantity

10 mg

Molecular Formula

C32H35ClFN7O2

CAS

2326521-71-3

Target

Ras GTPase Inhibitors

Purity

98%

Other Options

Image Product Name Manufacturer Price Range
7239460
Tocris Bioscience™ MRTX 849
Fischer Scientific --
74-885-0
Tocris Bioscience™ MRTX 849
Fischer Scientific ₹ 1,26,628.80
50-225-9181
Medchemexpress LLC HY-130149 500mg , Adagrasib CAS:2326521-71-3 Purity:>98%
Medchemexpress LLC ₹ 1,34,757.00
50-202-8941
Medchemexpress LLC HY-130149 10mg Medchemexpress, MRTX849 CAS:2326521-71-3 Purity:>98%
Medchemexpress LLC ₹ 10,331.37
NC1782126
Chemie Tek MRTX849 | 2326521-71-3 | MFCD32263433 | 10mg
Chemie Tek ₹ 8,384.88
NC2390053
eMolecules​ Adagrasib (MRTX849) | 2326521-71-3 | | 5mg
eMolecules​ ₹ 30,315.62
AZ90398
2326521-71-3 | 2-Piperazineacetonitrile, 4-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2S)-
A2B Chem ₹ 3,422.40 - ₹ 1,48,532.16

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Description

  • MRTX 849 is a mutant-selective inhibitor of KRASG12C (IC50 = 142 nM)
  • MRTX 849 covalently binds to KRASG12C at the cysteine at residue 12 and inhibits KRAS-dependent signal transduction by locking the protein in its inactive GDP-bound state
  • MRTX 849 induces pronounced tumor regression in 17 of 26 (65%) KRASG12C -positive cell lines and patient-derived xenograft models from multiple tumor types
  • It is orally bioavailable.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C

Compare Similar Items

Show Difference

Img

Fischer Scientific

74-881-0

--


Chemical Name or Material:
4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile

Quantity:
10 mg

Molecular Formula:
C32H35ClFN7O2

CAS:
2326521-71-3

Target:
Ras GTPase Inhibitors

Purity:
98%

Img

Fischer Scientific

74-885-0

--


Chemical Name or Material:
4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile

Quantity:
50 mg

Molecular Formula:
C32H35ClFN7O2

CAS:
2326521-71-3

Target:
Ras GTPase Inhibitors

Purity:
98%

Img

Fischer Scientific

74-891-0

--


Chemical Name or Material:
Ethyl (4 R,5 R)-rel-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1 H-imidazole-4-carboxylate

Quantity:
10 mg

Molecular Formula:
C39H37N3O3

CAS:
1446350-60-2

Target:
Proteasome Modulators

Purity:
0.98

Img

Fischer Scientific

74-895-0

--


Chemical Name or Material:
Ethyl (4 R,5 R)-rel-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1 H-imidazole-4-carboxylate

Quantity:
50 mg

Molecular Formula:
C39H37N3O3

CAS:
1446350-60-2

Target:
Proteasome Modulators

Purity:
0.98