7250137
Tocris Bioscience™ AMG 510
Potent and selective KRASG12C inhibitor
Manufacturer: Fischer Scientific
CAS Number: 2252403-56-6
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Chemical Name or Material
(1 R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2 S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1 H)-one
Target
Ras GTPase Inhibitors
Purity
0.98
CAS
2252403-56-6
Molecular Formula
C30H30F2N6O3
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ AMG 510 | Fischer Scientific | ₹ 19,079.88 | |
| | Tocris Bioscience™ AMG 510 | Fischer Scientific | ₹ 79,699.14 | |
 | Medchemexpress LLC AMG-510 | 2252403-56-6 | MFCD32062763 | 10 mM * 1 mL in DMSO | Medchemexpress LLC | ₹ 9,972.02 | |
 | 2252403-56-6 | Pyrido[2,3-d]pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]- | A2B Chem | ₹ 15,828.60 - ₹ 22,587.84 |
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Description
- AMG 510 is a potent and selective covalent KRASG12C inhibitor (IC50 = 90 nM)
- Also a potent inhibitor of phospho-ERK (IC50 = 68 nM)
- In an in vivo model of non-small cell lung cancer, AMG 510 causes regression of tumors, an increase in T-cell recruitment and a pro-inflammatory tumor microenvironment
- Synergises with MEK inhibitors and Carboplatin (Cat
- No
- 2626) and is orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: (1 R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2 S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1 H)-one
Target: Ras GTPase Inhibitors
Purity: 0.98
CAS: 2252403-56-6
Molecular Formula: C30H30F2N6O3
Chemical Name or Material:
(1 R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2 S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1 H)-one
Target:
Ras GTPase Inhibitors
Purity:
0.98
CAS:
2252403-56-6
Molecular Formula:
C30H30F2N6O3
Chemical Name or Material: N-[2-[[(2 S)-2-Methyl-1-pyrrolidinyl]methyl]-1 H-benzimidazol-6-yl]-6-isoquinolinecarboxamide
Target: Bromodomain Inhibitors
Purity: 0.98
CAS: 2561471-13-2
Molecular Formula: C23H23N5O
Chemical Name or Material:
N-[2-[[(2 S)-2-Methyl-1-pyrrolidinyl]methyl]-1 H-benzimidazol-6-yl]-6-isoquinolinecarboxamide
Target:
Bromodomain Inhibitors
Purity:
0.98
CAS:
2561471-13-2
Molecular Formula:
C23H23N5O
Chemical Name or Material: N-Hydroxy-2,2-dimethyl-N-(phenylmethyl)butanamide
Target: RIP Kinase Inhibitors
Purity: 0.98
CAS: 1956370-21-0
Molecular Formula: C13H19NO2
Chemical Name or Material:
N-Hydroxy-2,2-dimethyl-N-(phenylmethyl)butanamide
Target:
RIP Kinase Inhibitors
Purity:
0.98
CAS:
1956370-21-0
Molecular Formula:
C13H19NO2
Chemical Name or Material: N-[2-(3,4-Dimethoxyphenyl)ethyl]-6-methylthieno[2,3-d]pyrimidin-4-amine hydrochloride
Target: Additional Nuclear Receptor Compounds
Purity: 0.98
CAS: 1049691-47-5
Molecular Formula: C17H19N3O2S.HCl
Chemical Name or Material:
N-[2-(3,4-Dimethoxyphenyl)ethyl]-6-methylthieno[2,3-d]pyrimidin-4-amine hydrochloride
Target:
Additional Nuclear Receptor Compounds
Purity:
0.98
CAS:
1049691-47-5
Molecular Formula:
C17H19N3O2S.HCl