7146008

Tocris Bioscience™ JQEZ5

Potent and selective SAM-competitive EZH2 inhibitor

Manufacturer: Fischer Scientific

CAS Number: 1913252-04-6

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Chemical Name or Material

N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

CAS

1913252-04-6

Molecular Formula

C30H38N8O2

Purity

98%

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Description

  • Potent and selective SAM-competitive EZH2 lysine methyltransferase inhibitor (IC50 = 11 nM)
  • Selectively binds EZH2 over a panel of 22 methyltransferases
  • Reduces global level of the PRC2-associated mark H3K27me3 in K562 cells
  • Suppresses cell growth in CML cells
  • Inhibits colony formation of primary human CD34+ CML stem/ progenitor cells
  • Antitumor effects in vivo .

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C

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Chemical Name or Material:
N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

CAS:
1913252-04-6

Molecular Formula:
C30H38N8O2

Purity:
98%

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