7146008
Tocris Bioscience™ JQEZ5
Potent and selective SAM-competitive EZH2 inhibitor
Manufacturer: Fischer Scientific
CAS Number: 1913252-04-6
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Chemical Name or Material
N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
CAS
1913252-04-6
Molecular Formula
C30H38N8O2
Purity
98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ JQEZ5 | Fischer Scientific | ₹ 21,680.40 | |
| | Tocris Bioscience™ JQEZ5 | Fischer Scientific | ₹ 90,541.48 | |
 | Selleck Chemical LLC JQ-EZ-05 (JQEZ5) 2mg 1913252-04-6 | Selleck Chemical LLC | ₹ 15,699.60 | |
 | eMolecules Medchem Express / JQEZ5 / 5mg / 446256186 / HY-100846 / / 1913252-04-6 / [null] / 542.688 / C30H38N8O2 | eMolecules | ₹ 12,445.76 | |
 | N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxamide | Aaron Chemicals LLC | ₹ 12,727.00 - ₹ 1,36,170.00 | |
 | 1913252-04-6 | N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxamide | A2B Chem | ₹ 8,811.00 - ₹ 65,059.00 |
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Description
- Potent and selective SAM-competitive EZH2 lysine methyltransferase inhibitor (IC50 = 11 nM)
- Selectively binds EZH2 over a panel of 22 methyltransferases
- Reduces global level of the PRC2-associated mark H3K27me3 in K562 cells
- Suppresses cell growth in CML cells
- Inhibits colony formation of primary human CD34+ CML stem/ progenitor cells
- Antitumor effects in vivo .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
CAS: 1913252-04-6
Molecular Formula: C30H38N8O2
Purity: 98%
Chemical Name or Material:
N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
CAS:
1913252-04-6
Molecular Formula:
C30H38N8O2
Purity:
98%
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