7239453
Tocris Bioscience™ Adavosertib
Potent and selective Wee1 inhibitor
Manufacturer: Fischer Scientific
CAS Number: 955365-80-7
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Chemical Name or Material
1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3 H-pyrazolo[3,4-d]pyrimidin-3-one
Target
Checkpoint Control Kinase Inhibitors
Purity
98%
CAS
955365-80-7
Molecular Formula
C27H32N8O2
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Description
- Adavosertib is a potent and selective Wee1 inhibitor (IC50 = 5.2 nM)
- In a panel of 223 serine/threonine or tyrosine kinases, Adavosertib is highly selective for Wee 1 over all except 8 kinases
- In particular Adavosertib shows >100-fold selectivity over human Myt1
- Adavosertib blocks CDC2Y15 phosphorylation and Gemcitabine (Cat
- No
- 3259)-induced DNA damage checkpoint, leading to premature mitotic entry and apoptosis in p53-deficient tumor cell lines
- Adavosertib also potentiates the cytotoxic effects of Pemetrexed (Cat
- No
- 6185), Doxorubicin (Cat
- No
- 2252), Camptothecin (Cat
- No
- 1100) and Mitomycin C (Cat
- No
- 3258) in vitro
- Adavosertib synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3 H-pyrazolo[3,4-d]pyrimidin-3-one
Target: Checkpoint Control Kinase Inhibitors
Purity: 98%
CAS: 955365-80-7
Molecular Formula: C27H32N8O2
Chemical Name or Material:
1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3 H-pyrazolo[3,4-d]pyrimidin-3-one
Target:
Checkpoint Control Kinase Inhibitors
Purity:
98%
CAS:
955365-80-7
Molecular Formula:
C27H32N8O2
Chemical Name or Material: __
Target: __
Purity: __
CAS: __
Molecular Formula: __
Chemical Name or Material:
__
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Chemical Name or Material: 4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile
Target: Ras GTPase Inhibitors
Purity: 98%
CAS: 2326521-71-3
Molecular Formula: C32H35ClFN7O2
Chemical Name or Material:
4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile
Target:
Ras GTPase Inhibitors
Purity:
98%
CAS:
2326521-71-3
Molecular Formula:
C32H35ClFN7O2
Chemical Name or Material: __
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Purity: __
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