75-895-0
Tocris Bioscience™ Adavosertib
Manufacturer: Fischer Scientific
CAS Number: 955365-80-7
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 75-895-0-Each-of-1 | In Stock | ₹ 88,041.24 |
75-895-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 88,041.24
GST (18%): ₹ 15,847.423
Total Price: ₹ 1,03,888.663
Chemical Name or Material
1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3 H-pyrazolo[3,4-d]pyrimidin-3-one
Quantity
50 mg
Molecular Formula
C27H32N8O2
CAS
955365-80-7
Target
Checkpoint Control Kinase Inhibitors
Purity
98%
Other Options
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Description
- Adavosertib is a potent and selective Wee1 inhibitor (IC50 = 5.2 nM)
- In a panel of 223 serine/threonine or tyrosine kinases, Adavosertib is highly selective for Wee 1 over all except 8 kinases
- In particular Adavosertib shows >100-fold selectivity over human Myt1
- Adavosertib blocks CDC2Y15 phosphorylation and Gemcitabine (Cat
- No
- 3259)-induced DNA damage checkpoint, leading to premature mitotic entry and apoptosis in p53-deficient tumor cell lines
- Adavosertib also potentiates the cytotoxic effects of Pemetrexed (Cat
- No
- 6185), Doxorubicin (Cat
- No
- 2252), Camptothecin (Cat
- No
- 1100) and Mitomycin C (Cat
- No
- 3258) in vitro
- Adavosertib synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3 H-pyrazolo[3,4-d]pyrimidin-3-one
Quantity: 50 mg
Molecular Formula: C27H32N8O2
CAS: 955365-80-7
Target: Checkpoint Control Kinase Inhibitors
Purity: 98%
Chemical Name or Material:
1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3 H-pyrazolo[3,4-d]pyrimidin-3-one
Quantity:
50 mg
Molecular Formula:
C27H32N8O2
CAS:
955365-80-7
Target:
Checkpoint Control Kinase Inhibitors
Purity:
98%
Chemical Name or Material: __
Quantity: 100 μg
Molecular Formula: __
CAS: __
Target: __
Purity: __
Chemical Name or Material:
__
Quantity:
100 μg
Molecular Formula:
__
CAS:
__
Target:
__
Purity:
__
Chemical Name or Material: N-[5-[(5-Chloro-1 H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
Quantity: 10 mg
Molecular Formula: C20H15ClF3N5
CAS: 1029044-16-3
Target: Additional RTK Inhibitors
Purity: 98%
Chemical Name or Material:
N-[5-[(5-Chloro-1 H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
Quantity:
10 mg
Molecular Formula:
C20H15ClF3N5
CAS:
1029044-16-3
Target:
Additional RTK Inhibitors
Purity:
98%
Chemical Name or Material: N-[5-[(5-Chloro-1 H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
Quantity: 50 mg
Molecular Formula: C20H15ClF3N5
CAS: 1029044-16-3
Target: Additional RTK Inhibitors
Purity: 98%
Chemical Name or Material:
N-[5-[(5-Chloro-1 H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
Quantity:
50 mg
Molecular Formula:
C20H15ClF3N5
CAS:
1029044-16-3
Target:
Additional RTK Inhibitors
Purity:
98%