Tasquinimod is a high affinity negative allosteric modulator of HDAC4 (Kd = 10 - 30 nM)
Binds the regulatory Zn2+ binding domain of HDAC4
Suppresses hypoxia-induced decrease in histone acetylation in human prostate cancer cells in vitro
Also binds S100A9
Antiangiogenic
Inhibits endothelial sprouting in vitro and growth of prostate tumor xenografts in nude mice
Orally bioavailable.
SAFETY INFORMATION
Recommended Storage : Store kit components at the temperatures indicated on the labels and insert until their expiration dateStore HeLa Whole Cell Extract at -80°C. Avoid repeated freeze-thaw cycles. Stable (at -80°C for 6 months)