7110786

Tocris Bioscience™ QO 58

Kv7 channel opener

Manufacturer: Fischer Scientific

CAS Number: 1259536-62-3

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Chemical Name or Material

5-(2,6-Dichloro-5-fluoro-3-pyridinyl)-3-phenyl-2-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidin-7(4H)-one

Target

Voltage-gated Potassium Channel Activators

Formula Weight

443.18

CAS

1259536-62-3

Molecular Formula

C18H8Cl2F4N4O

Purity

>98%

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Description

  • Description Kv7 channel opener (EC50 values are 0.6, 1.0, 5.2 and 7.0 μM for Kv7.4, Kv7.2, Kv7.3/7.5 and Kv7.1, respectively)
  • Increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo model.

SAFETY INFORMATION

  • Recommended Storage : Store at 4°C