7110794
Tocris Bioscience™ CLP 257
Selective KCC2 activator
Manufacturer: Fischer Scientific
CAS Number: 1181081-71-9
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Chemical Name or Material
(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone
Target
KCC2 Activators
Formula Weight
307.34
CAS
1181081-71-9
Molecular Formula
C14H14FN3O2S
Purity
>98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ CLP 257 | Fischer Scientific | ₹ 26,566.38 | |
| | Tocris Bioscience™ CLP 257 | Fischer Scientific | ₹ 1,10,115.72 | |
 | Medchemexpress LLC HY-110143 5mg Medchemexpress, CLP257 CAS:1181081-71-9 Purity:>98% | Medchemexpress LLC | ₹ 9,882.18 | |
 | Sigma Aldrich Fine Chemicals Biosciences CLP257 >=98% (HPLC) | 1181081-71-9 | MFCD28166488 | 5MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 14,254.30 | |
 | CLP257 | ChemScene | ₹ 9,411.60 - ₹ 89,410.20 | |
 | 1181081-71-9 | CLP257 | A2B Chem | ₹ 2,481.24 - ₹ 39,100.92 |
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Description
- Selective KCC2 K+-Cl- cotransporter activator (EC50 = 616 nM)
- Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, as well as 55 other receptors
- Enhances Cl- transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function
- Alleviates hypersensitivity in rats with peripheral nerve injury.
SAFETY INFORMATION
- Recommended Storage : Store at 4°C
Compare Similar Items
Show Difference
Chemical Name or Material: (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone
Target: KCC2 Activators
Formula Weight: 307.34
CAS: 1181081-71-9
Molecular Formula: C14H14FN3O2S
Purity: >98%
Chemical Name or Material:
(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone
Target:
KCC2 Activators
Formula Weight:
307.34
CAS:
1181081-71-9
Molecular Formula:
C14H14FN3O2S
Purity:
>98%
Chemical Name or Material: 4-[4-(1-Methyl-1H-pyrazole-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]benzonitrile
Target: Bromodomain Inhibitors
Formula Weight: 357.41
CAS: __
Molecular Formula: C20H19N7
Purity: >98%
Chemical Name or Material:
4-[4-(1-Methyl-1H-pyrazole-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]benzonitrile
Target:
Bromodomain Inhibitors
Formula Weight:
357.41
CAS:
__
Molecular Formula:
C20H19N7
Purity:
>98%
Chemical Name or Material: 2-Amino-N-[(1 R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3 H-indole-3,4 '-piperidin]-1 '-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide methanesulfonate
Target: Ghrelin Receptor Agonists
Formula Weight: 624.77
CAS: 159752-10-0
Molecular Formula: C27H36N4O5S.CH3SO3H
Purity: 98%
Chemical Name or Material:
2-Amino-N-[(1 R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3 H-indole-3,4 '-piperidin]-1 '-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide methanesulfonate
Target:
Ghrelin Receptor Agonists
Formula Weight:
624.77
CAS:
159752-10-0
Molecular Formula:
C27H36N4O5S.CH3SO3H
Purity:
98%
Chemical Name or Material: 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride
Target: AMPK Activators
Formula Weight: 361.69
CAS: __
Molecular Formula: C13H13BrN2OS.HCl
Purity: >99%
Chemical Name or Material:
2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride
Target:
AMPK Activators
Formula Weight:
361.69
CAS:
__
Molecular Formula:
C13H13BrN2OS.HCl
Purity:
>99%