7110798

Tocris Bioscience™ MK 0677

High affinity ghrelin receptor agonist

Manufacturer: Fischer Scientific

CAS Number: 159752-10-0

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Chemical Name or Material

2-Amino-N-[(1 R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3 H-indole-3,4 '-piperidin]-1 '-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide methanesulfonate

Synonym

Ibutamoren mesylate, L-163,191

Molecular Formula

C27H36N4O5S.CH3SO3H

Purity

98%

CAS

159752-10-0

Target

Ghrelin Receptor Agonists

Formula Weight

624.77

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Description

  • High affinity ghrelin receptor agonist (pKi = 8.14)
  • Growth hormone (GH) secretagog; stimulates GH release from rat pituitary cells in vitro (EC50 = 1.3 nM) and enhances GH plasma levels in vivo
  • Also attenuates isoproterenol -induced lipolysis in rat adipocytes in vitro
  • Orally bioavailable.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C