7110880

Tocris Bioscience™ IP7e

Potent Nurr1 activator

Manufacturer: Fischer Scientific

CAS Number: 500164-74-9

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Chemical Name or Material

6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one

Target

NFkB/IkB Inhibitors

Formula Weight

390.43

CAS

500164-74-9

Molecular Formula

C23H22N2O4

Purity

>98%

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Description

  • Potent Nurr1 activator (EC50 = 3.9 nM)
  • Delays onset and reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE)
  • Also suppresses NF-κB signaling
  • Brain penetrant and orally bioavailable.

SAFETY INFORMATION

  • Recommended Storage : Store at 4°C