7112854

Tocris Bioscience™ MPEP hydrochloride

Potent mGlu5 antagonist; also positive allosteric modulator of mGlu4 receptors

Manufacturer: Fischer Scientific

CAS Number: 219911-35-0

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Chemical Name or Material

2-Methyl-6-(phenylethynyl)pyridine hydrochloride

Assay Percent Range

>99%

Target

Group I mGluR Antagonists

Formula Weight

Observed MW: 229.71

CAS

219911-35-0

Solubility

Soluble to 100mM in DMSO

Molecular Formula

C14H11N.HCl

Purity

99%

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Description

  • Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors
  • Centrally active following systemic administration in vivo
  • Reverses mechanical hyperalgesia in the inflamed rat hind paw.

SAFETY INFORMATION

  • Recommended Storage : Desiccate at +4°C

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Fischer Scientific

7112854

Potent mGlu5 antagonist; also posit...


Chemical Name or Material:
2-Methyl-6-(phenylethynyl)pyridine hydrochloride

Assay Percent Range:
>99%

Target:
Group I mGluR Antagonists

Formula Weight:
Observed MW: 229.71

CAS:
219911-35-0

Solubility:
Soluble to 100mM in DMSO

Molecular Formula:
C14H11N.HCl

Purity:
99%

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7112856

Selective 5-HT1B antagonist...


Chemical Name or Material:
1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine hydrochloride

Assay Percent Range:
>95%

Target:
__

Formula Weight:
Observed MW: 557.09

CAS:
180084-26-8

Solubility:
Soluble to 10mM with gentle warming in DMSO

Molecular Formula:
C32H32N4O3.HCl

Purity:
__

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7112858

Activates Cl- conductance and hKCa3...


Chemical Name or Material:
5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one

Assay Percent Range:
>99%

Target:
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Formula Weight:
Observed MW: 231.08

CAS:
60563-36-2

Solubility:
Soluble to 100mM in DMSO

Molecular Formula:
C9H8Cl2N2O

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Chemical Name or Material:
5-(2-Aminoethyl)-4-methylimidazole dihydrochloride

Assay Percent Range:
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Formula Weight:
Observed MW: 198.09

CAS:
36376-47-3

Solubility:
Soluble to 50mM in water

Molecular Formula:
C6H11N3.2HCl

Purity:
__