7114679
Tocris Bioscience™ Lonafarnib
Potent farnesyl transferase inhibitor
Manufacturer: Fischer Scientific
CAS Number: 193275-84-2
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Chemical Name or Material
4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide
Assay Percent Range
>98%
Formula Weight
Observed MW: 638.82
CAS
193275-84-2
Molecular Formula
C27H31Br2ClN4O2
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ Lonafarnib | Fischer Scientific | ₹ 17,043.55 | |
| | Tocris Bioscience™ Lonafarnib | Fischer Scientific | ₹ 70,587.00 | |
 | Medchemexpress LLC HY-15136 10mg , Lonafarnib CAS:193275-84-2 Purity:>98% | Medchemexpress LLC | ₹ 17,069.22 | |
 | Selleck Chemical LLC Lonafarnib 5mg 193275-84-2 SCH66336 | Selleck Chemical LLC | ₹ 17,454.24 | |
 | Sigma Aldrich Fine Chemicals Biosciences Lonafarnib | 193275-84-2 | MFCD06795138 | 5mg | Sigma Aldrich Fine Chemicals Biosciences | ₹ 14,463.92 |
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Description
- Potent farnesyl transferase inhibitor (IC50 = 1.9 nM)
- Inhibits farnesylation of RAS
- Also inhibits Pgp transport (IC50 < 3 μM) and increases potency and anticancer activity when used in conjunction with cytotoxic Pgp substrates
- Inhibits neovascularization by affecting cell motility
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide
Assay Percent Range: >98%
Formula Weight: Observed MW: 638.82
CAS: 193275-84-2
Molecular Formula: C27H31Br2ClN4O2
Chemical Name or Material:
4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide
Assay Percent Range:
>98%
Formula Weight:
Observed MW: 638.82
CAS:
193275-84-2
Molecular Formula:
C27H31Br2ClN4O2
Chemical Name or Material: 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6 H-pyrrolo[4,3,2,ef][2 ]benzazepin-6-one (1 S,4 R)-7,7-dimethyl-2-oxobicyclo[2.2.1 ]heptane-1-methanesulfonic acid
Assay Percent Range: >98%
Formula Weight: Observed MW: 555.66
CAS: 1859053-21-6
Molecular Formula: C19H18FN3O.C10H16O4S
Chemical Name or Material:
8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6 H-pyrrolo[4,3,2,ef][2 ]benzazepin-6-one (1 S,4 R)-7,7-dimethyl-2-oxobicyclo[2.2.1 ]heptane-1-methanesulfonic acid
Assay Percent Range:
>98%
Formula Weight:
Observed MW: 555.66
CAS:
1859053-21-6
Molecular Formula:
C19H18FN3O.C10H16O4S
Chemical Name or Material: (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide
Assay Percent Range: >98%
Formula Weight: Observed MW: 469.94
CAS: 1110813-31-4
Molecular Formula: C24H25ClFN5O2
Chemical Name or Material:
(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide
Assay Percent Range:
>98%
Formula Weight:
Observed MW: 469.94
CAS:
1110813-31-4
Molecular Formula:
C24H25ClFN5O2
Chemical Name or Material: 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one
Assay Percent Range: >98%
Formula Weight: Observed MW: 328.67
CAS: 2036081-86-2
Molecular Formula: C14H8ClF3N2O2
Chemical Name or Material:
5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one
Assay Percent Range:
>98%
Formula Weight:
Observed MW: 328.67
CAS:
2036081-86-2
Molecular Formula:
C14H8ClF3N2O2