7161599
Tocris Bioscience™ Avagacestat
Highly potent γ-secretase inhibitor; orally bioavailable
Manufacturer: Fischer Scientific
CAS Number: 1146699-66-2
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Chemical Name or Material
(2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
Synonym
BMS-708163
Formula Weight
520.89
CAS
1146699-66-2
Molecular Formula
C20H17ClF4N4O4S
Purity
98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ Avagacestat | Fischer Scientific | ₹ 34,241.11 | |
| | Tocris Bioscience™ Avagacestat | Fischer Scientific | ₹ 8,932.46 | |
 | Apexbio Technology LLC BMS-708163 (Avagacestat), 2mg. Cas: 1146699-66-2 MFCD: MFCD13195458. γ-secretase inhibitor | Apexbio Technology LLC | ₹ 6,759.24 | |
 | Selleck Chemical LLC Avagacestat (BMS-708163) 5mg 1146699-66-2 | Selleck Chemical LLC | ₹ 17,454.24 | |
 | Pentanamide, 2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-, (2R)- | Aaron Chemicals LLC | ₹ 1,711.20 - ₹ 27,892.56 | |
 | Avagacestat | ChemScene | ₹ 6,160.32 - ₹ 82,137.60 |
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Description
- Highly potent γ-secretase inhibitor (Aβ40 IC50 = 0.3 nM) Exhibits >137-fold selectivity for amyloid-β precursor protein (APP) processing over Notch Reduces plasma and brain Aβ40 and Aβ42 levels in vivo Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at 4°C
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Chemical Name or Material: (2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
Synonym: BMS-708163
Formula Weight: 520.89
CAS: 1146699-66-2
Molecular Formula: C20H17ClF4N4O4S
Purity: 98%
Chemical Name or Material:
(2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
Synonym:
BMS-708163
Formula Weight:
520.89
CAS:
1146699-66-2
Molecular Formula:
C20H17ClF4N4O4S
Purity:
98%
Chemical Name or Material: 2-[[[2-[[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]benzonitrile
Synonym: __
Formula Weight: 629.75
CAS: 2016806-57-6
Molecular Formula: C33H36FN7O3S
Purity: 98%
Chemical Name or Material:
2-[[[2-[[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]benzonitrile
Synonym:
__
Formula Weight:
629.75
CAS:
2016806-57-6
Molecular Formula:
C33H36FN7O3S
Purity:
98%
Chemical Name or Material: 7-Fluoro-6-[6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethyl]amino]-3-quinolinecarboxamide
Synonym: __
Formula Weight: 434.47
CAS: 1941214-06-7
Molecular Formula: C23H23FN6O2
Purity: 98%
Chemical Name or Material:
7-Fluoro-6-[6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethyl]amino]-3-quinolinecarboxamide
Synonym:
__
Formula Weight:
434.47
CAS:
1941214-06-7
Molecular Formula:
C23H23FN6O2
Purity:
98%
Chemical Name or Material: [3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur
Synonym: __
Formula Weight: 558.53
CAS: 1448316-08-2
Molecular Formula: C26H19F5N6OS
Purity: 98%
Chemical Name or Material:
[3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur
Synonym:
__
Formula Weight:
558.53
CAS:
1448316-08-2
Molecular Formula:
C26H19F5N6OS
Purity:
98%