7250133
Tocris Bioscience™ SJ 6986
Molecular glue; induces degradation of GSPT1/2
Manufacturer: Fischer Scientific
CAS Number: 2765625-93-0
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Chemical Name or Material
N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide
Target
Molecular Glues
Purity
0.98
CAS
2765625-93-0
Molecular Formula
C20H14F3N3O7S
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ SJ 6986 | Fischer Scientific | ₹ 21,261.66 | |
| | Tocris Bioscience™ SJ 6986 | Fischer Scientific | ₹ 88,725.72 | |
 | eMolecules Medchem Express / SJ6986 / 5mg / 632896500 / HY-132199 / / 2765625-93-0 / [null] / 497.400 / C20H14F3N3O7S | eMolecules | ₹ 7,556.66 |
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Description
- SJ 6986 is a potent and selective GSPT1/2 molecular glue Degrader (DC50 = 2.1 nM)
- The Degrader exhibits antiproliferative effects in human medulloblastoma and leukemia cell lines
- (EC50 values are 0.4 nM, 1.5 nM, 336 nM, 726 nM and 3583 nM in MHH-CALL-4, MV4-11, MB004, MB002 and HD-MB03 cell lines, respectively)
- In vivo , SJ 6986 is stable in mouse (t1/2 = 4.7 h)
- This product is orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide
Target: Molecular Glues
Purity: 0.98
CAS: 2765625-93-0
Molecular Formula: C20H14F3N3O7S
Chemical Name or Material:
N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide
Target:
Molecular Glues
Purity:
0.98
CAS:
2765625-93-0
Molecular Formula:
C20H14F3N3O7S
Chemical Name or Material: 2,4-Dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-3 H-1,2,4-triazole-3-thione
Target: Antiviral Compounds
Purity: 0.98
CAS: 675104-49-1
Molecular Formula: C12H12N4O2S2
Chemical Name or Material:
2,4-Dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-3 H-1,2,4-triazole-3-thione
Target:
Antiviral Compounds
Purity:
0.98
CAS:
675104-49-1
Molecular Formula:
C12H12N4O2S2
Chemical Name or Material: (1 R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2 S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1 H)-one
Target: Ras GTPase Inhibitors
Purity: 0.98
CAS: 2252403-56-6
Molecular Formula: C30H30F2N6O3
Chemical Name or Material:
(1 R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2 S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1 H)-one
Target:
Ras GTPase Inhibitors
Purity:
0.98
CAS:
2252403-56-6
Molecular Formula:
C30H30F2N6O3
Chemical Name or Material: N-[2-[[(2 S)-2-Methyl-1-pyrrolidinyl]methyl]-1 H-benzimidazol-6-yl]-6-isoquinolinecarboxamide
Target: Bromodomain Inhibitors
Purity: 0.98
CAS: 2561471-13-2
Molecular Formula: C23H23N5O
Chemical Name or Material:
N-[2-[[(2 S)-2-Methyl-1-pyrrolidinyl]methyl]-1 H-benzimidazol-6-yl]-6-isoquinolinecarboxamide
Target:
Bromodomain Inhibitors
Purity:
0.98
CAS:
2561471-13-2
Molecular Formula:
C23H23N5O