75-835
Tocris Bioscience™ SK 575
Manufacturer: Tocris Bioscience™
CAS Number: 2523016-96-6
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 75-835-Each-of-1 | In Stock | ₹ 40,272.50 |
75-835 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,272.50
GST (18%): ₹ 7,249.05
Total Price: ₹ 47,521.55
Chemical Name or Material
N-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-12-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-12-oxododecanamide
Quantity
5 mg
Molecular Formula
C47H53FN8O8
CAS
2523016-96-6
Target
PARP
Purity
0.98
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | eMolecules Medchem Express / SK-575 / 5mg / 771358833 / HY-139156 / / 2523016-96-6 / [null] / 876.987 / C47H53FN8O8 | eMolecules | ₹ 41,193.65 | |
 | 2523016-96-6 | SK-575 | A2B Chem | ₹ 31,595.00 - ₹ 2,38,965.00 |
Related Products
Description
- SK 575 is a potent PARP1 Degrader (PROTAC®; DC50 ≤ 6.72 nM, >99% PARP1 degradation at 10 nM)
- It comprises the PARP1/2 inhibitor Olaparib (Cat
- No
- 7579), joined by a linker to cereblon/cullin 4A ligand Thalidomide (Cat
- No
- 0652)
- SK 575 inhibits the growth of various cancer cell lines bearing BRCA1/2 mutations with IC50 values in the nanomolar range
- It effectively reduces PARP1 protein levels in mouse SW620 tumor xenograft models
- SK 575 dose-dependently potentiates the antitumor activity of Temozolomide (Cat
- No
- 2706) and Cisplatin (Cat
- No
- 2251) in vivo
- PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: N-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-12-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-12-oxododecanamide
Quantity: 5 mg
Molecular Formula: C47H53FN8O8
CAS: 2523016-96-6
Target: PARP
Purity: 0.98
Chemical Name or Material:
N-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-12-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-12-oxododecanamide
Quantity:
5 mg
Molecular Formula:
C47H53FN8O8
CAS:
2523016-96-6
Target:
PARP
Purity:
0.98
Chemical Name or Material: (1 'R,3 'S)-3 '-Fluoro-N-[(4-fluorophenyl)methyl]-2 ',3 '-dihydro-5 '-[1-[2-(methylamino)-2-oxoethyl]-1 H-pyrazol-4-yl]-2,5-dioxo-N-[(1 S)-2,2,2-trifluoro-1-methylethyl]spiro[imidazolidine-4,1 '-[1 H]indene]-1-acetamide
Quantity: 5 mg
Molecular Formula: C29H27F5N6O4
CAS: __
Target: Histone Acetyltransferase Inhibitors
Purity: 98%
Chemical Name or Material:
(1 'R,3 'S)-3 '-Fluoro-N-[(4-fluorophenyl)methyl]-2 ',3 '-dihydro-5 '-[1-[2-(methylamino)-2-oxoethyl]-1 H-pyrazol-4-yl]-2,5-dioxo-N-[(1 S)-2,2,2-trifluoro-1-methylethyl]spiro[imidazolidine-4,1 '-[1 H]indene]-1-acetamide
Quantity:
5 mg
Molecular Formula:
C29H27F5N6O4
CAS:
__
Target:
Histone Acetyltransferase Inhibitors
Purity:
98%
Chemical Name or Material: β-D-N4-hydroxycytidine-5 '-isopropyl ester
Quantity: 10 mg
Molecular Formula: C13H19N3O7
CAS: 2492423-29-5
Target: Antiviral Compounds
Purity: 98%
Chemical Name or Material:
β-D-N4-hydroxycytidine-5 '-isopropyl ester
Quantity:
10 mg
Molecular Formula:
C13H19N3O7
CAS:
2492423-29-5
Target:
Antiviral Compounds
Purity:
98%
Chemical Name or Material: β-D-N4-hydroxycytidine-5 '-isopropyl ester
Quantity: 50 mg
Molecular Formula: C13H19N3O7
CAS: 2492423-29-5
Target: Antiviral Compounds
Purity: 98%
Chemical Name or Material:
β-D-N4-hydroxycytidine-5 '-isopropyl ester
Quantity:
50 mg
Molecular Formula:
C13H19N3O7
CAS:
2492423-29-5
Target:
Antiviral Compounds
Purity:
98%