76-825

Tocris Bioscience™ JQAD1

Manufacturer: Tocris Bioscience™

CAS Number: 2417097-18-6

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Pack Size SKU Availability Price
Each of 1 76-825-Each-of-1 In Stock ₹ 46,630.20

76-825 - Each of 1

₹ 46,630.20

In Stock

Quantity

1

Base Price: ₹ 46,630.20

GST (18%): ₹ 8,393.436

Total Price: ₹ 55,023.636

Chemical Name or Material

12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((R)-3 '-(2-((4-fluorobenzyl)(-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2 ',4 '-dioxo-2,3-dihydrospiro[indene-1,5 '-oxazolidin]-5-yl)dodecanamide

Quantity

5 mg

Molecular Formula

C48H52F4N6O9

CAS

2417097-18-6

Target

Active Degraders

Purity

98%

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Description

  • JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC™; DC50 ≤ 31.6 nM); comprises an EP300 inhibitor, A485 (Cat.No
  • 6387), joined by a linker to a cereblon E3 ligase ligand
  • JQAD1 brings about degradation of EP300 in neuroblastoma cell lines in a proteasome-dependent manner
  • JQAD1 suppresses both H3K27ac and EP300 expression levels and induces apoptosis
  • JQAD1 suppresses tumors growth in NSG mice xenografted with Kelly cells
  • CRC and MYCN genes are downregulated in tumors treated with JQAD1
  • JQAD1 exhibits no significant effect on coactivator CBP at concentrations inducing EP300 degradation
  • PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C

Compare Similar Items

Show Difference

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Tocris Bioscience™

76-825

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Chemical Name or Material:
12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((R)-3 '-(2-((4-fluorobenzyl)(-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2 ',4 '-dioxo-2,3-dihydrospiro[indene-1,5 '-oxazolidin]-5-yl)dodecanamide

Quantity:
5 mg

Molecular Formula:
C48H52F4N6O9

CAS:
2417097-18-6

Target:
Active Degraders

Purity:
98%

Img

Tocris Bioscience™

76-875

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Chemical Name or Material:
-13-((2 S,4 S)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecyl (R)-2-(-4-(4-chlorophenyl)-2,3,9-trimethyl-6 H-thieno[3,2-f][1,2,4 ]triazolo[4,3-a][1,4 ]diazepin-6-yl)butan

Quantity:
5 mg

Molecular Formula:
C51H63ClN8O9S2

CAS:
__

Target:
TAG Degradation Platforms

Purity:
98%

Img

Tocris Bioscience™

76-955

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Chemical Name or Material:
5-[5-[3-Chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl]-6-oxo[1(6 H),3 '-bipyridin]-3-yl]-1-methyl-2,4(1 H,3 H)-pyrimidinedione

Quantity:
5 mg

Molecular Formula:
C28H19Cl2FN4O4

CAS:
2679814-93-6

Target:
3 C and 3 CL Protease Inhibitors

Purity:
0.95

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Sigma Aldrich

760110

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Molecular Formula:
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CAS:
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