76-825
Tocris Bioscience™ JQAD1
Manufacturer: Tocris Bioscience™
CAS Number: 2417097-18-6
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 76-825-Each-of-1 | In Stock | ₹ 46,630.20 |
76-825 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,630.20
GST (18%): ₹ 8,393.436
Total Price: ₹ 55,023.636
Chemical Name or Material
12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((R)-3 '-(2-((4-fluorobenzyl)(-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2 ',4 '-dioxo-2,3-dihydrospiro[indene-1,5 '-oxazolidin]-5-yl)dodecanamide
Quantity
5 mg
Molecular Formula
C48H52F4N6O9
CAS
2417097-18-6
Target
Active Degraders
Purity
98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | eMolecules Medchem Express / JQAD1 / 5mg / 778475809 / HY-145765 / / 2417097-18-6 / [null] / 932.971 / C48H52F4N6O9 | eMolecules | ₹ 49,501.59 | |
 | 2417097-18-6 | 12-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((R)-3'-(2-((4-fluorobenzyl)((S)-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-5-yl)dodecanamide | A2B Chem | ₹ 6,502.56 - ₹ 29,090.40 |
Related Products
Description
- JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC™; DC50 ≤ 31.6 nM); comprises an EP300 inhibitor, A485 (Cat.No
- 6387), joined by a linker to a cereblon E3 ligase ligand
- JQAD1 brings about degradation of EP300 in neuroblastoma cell lines in a proteasome-dependent manner
- JQAD1 suppresses both H3K27ac and EP300 expression levels and induces apoptosis
- JQAD1 suppresses tumors growth in NSG mice xenografted with Kelly cells
- CRC and MYCN genes are downregulated in tumors treated with JQAD1
- JQAD1 exhibits no significant effect on coactivator CBP at concentrations inducing EP300 degradation
- PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((R)-3 '-(2-((4-fluorobenzyl)(-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2 ',4 '-dioxo-2,3-dihydrospiro[indene-1,5 '-oxazolidin]-5-yl)dodecanamide
Quantity: 5 mg
Molecular Formula: C48H52F4N6O9
CAS: 2417097-18-6
Target: Active Degraders
Purity: 98%
Chemical Name or Material:
12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((R)-3 '-(2-((4-fluorobenzyl)(-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2 ',4 '-dioxo-2,3-dihydrospiro[indene-1,5 '-oxazolidin]-5-yl)dodecanamide
Quantity:
5 mg
Molecular Formula:
C48H52F4N6O9
CAS:
2417097-18-6
Target:
Active Degraders
Purity:
98%
Chemical Name or Material: -13-((2 S,4 S)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecyl (R)-2-(-4-(4-chlorophenyl)-2,3,9-trimethyl-6 H-thieno[3,2-f][1,2,4 ]triazolo[4,3-a][1,4 ]diazepin-6-yl)butan
Quantity: 5 mg
Molecular Formula: C51H63ClN8O9S2
CAS: __
Target: TAG Degradation Platforms
Purity: 98%
Chemical Name or Material:
-13-((2 S,4 S)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecyl (R)-2-(-4-(4-chlorophenyl)-2,3,9-trimethyl-6 H-thieno[3,2-f][1,2,4 ]triazolo[4,3-a][1,4 ]diazepin-6-yl)butan
Quantity:
5 mg
Molecular Formula:
C51H63ClN8O9S2
CAS:
__
Target:
TAG Degradation Platforms
Purity:
98%
Chemical Name or Material: 5-[5-[3-Chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl]-6-oxo[1(6 H),3 '-bipyridin]-3-yl]-1-methyl-2,4(1 H,3 H)-pyrimidinedione
Quantity: 5 mg
Molecular Formula: C28H19Cl2FN4O4
CAS: 2679814-93-6
Target: 3 C and 3 CL Protease Inhibitors
Purity: 0.95
Chemical Name or Material:
5-[5-[3-Chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl]-6-oxo[1(6 H),3 '-bipyridin]-3-yl]-1-methyl-2,4(1 H,3 H)-pyrimidinedione
Quantity:
5 mg
Molecular Formula:
C28H19Cl2FN4O4
CAS:
2679814-93-6
Target:
3 C and 3 CL Protease Inhibitors
Purity:
0.95
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