69-715
Tocris Bioscience™ aTAG 4531
Manufacturer: Tocris Bioscience™
CAS Number: 2412985-00-1
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 69-715-Each-of-1 | In Stock | ₹ 50,374.00 |
69-715 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,374.00
GST (18%): ₹ 9,067.32
Total Price: ₹ 59,441.32
Chemical Name or Material
N-Cyclopropyl-6-(4-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)-1 H-1,2,3-triazol-1-yl)butyl)carbamoyl)-3-fluorophenyl)-7-fluoro-4-(phenylamino)quinoline-3-carboxamide
Quantity
5 mg
Molecular Formula
C46H39F2N9O7
CAS
2412985-00-1
Target
TAG Degradation Platforms
Purity
98%
Related Products
Description
- aTAG 4531 is a degrader of MTH1 fusion proteins for use within the aTAG system
- Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide (Cat
- No
- 0652)
- Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.34 nM; Dmax = 93.14%)
- Cell-permeable
- Suitable for in vitro and in vivo applications
- Mouse DMPK properties are provided in the supplementary file (see below)
- MTH1 can be expressed as a fusion with a target protein of interest using genome engineering techniques via CRISPR-mediated locus-specific knock-in
- See protocol for more information
- Custom knock-in cell lines for the dTAG and aTAG platforms are available from our sister brand R&D Systems
- Email TPD@bio-techne.com to enquire.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Show Difference
Chemical Name or Material: N-Cyclopropyl-6-(4-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)-1 H-1,2,3-triazol-1-yl)butyl)carbamoyl)-3-fluorophenyl)-7-fluoro-4-(phenylamino)quinoline-3-carboxamide
Quantity: 5 mg
Molecular Formula: C46H39F2N9O7
CAS: 2412985-00-1
Target: TAG Degradation Platforms
Purity: 98%
Chemical Name or Material:
N-Cyclopropyl-6-(4-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)-1 H-1,2,3-triazol-1-yl)butyl)carbamoyl)-3-fluorophenyl)-7-fluoro-4-(phenylamino)quinoline-3-carboxamide
Quantity:
5 mg
Molecular Formula:
C46H39F2N9O7
CAS:
2412985-00-1
Target:
TAG Degradation Platforms
Purity:
98%
Chemical Name or Material: __
Quantity: 100 Tests
Molecular Formula: __
CAS: __
Target: __
Purity: __
Chemical Name or Material:
__
Quantity:
100 Tests
Molecular Formula:
__
CAS:
__
Target:
__
Purity:
__
Chemical Name or Material: N-[(2,4-Difluorophenyl)methyl]-2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl][1,1'-biphenyl]-2-carboxamide
Quantity: 25 mg
Molecular Formula: C30H26F2N2O3
CAS: 498577-46-1
Target: __
Purity: 98%
Chemical Name or Material:
N-[(2,4-Difluorophenyl)methyl]-2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl][1,1'-biphenyl]-2-carboxamide
Quantity:
25 mg
Molecular Formula:
C30H26F2N2O3
CAS:
498577-46-1
Target:
__
Purity:
98%
Chemical Name or Material: N-[(2,4-Difluorophenyl)methyl]-2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl][1,1'-biphenyl]-2-carboxamide
Quantity: 5 mg
Molecular Formula: C30H26F2N2O3
CAS: 498577-46-1
Target: __
Purity: 98%
Chemical Name or Material:
N-[(2,4-Difluorophenyl)methyl]-2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl][1,1'-biphenyl]-2-carboxamide
Quantity:
5 mg
Molecular Formula:
C30H26F2N2O3
CAS:
498577-46-1
Target:
__
Purity:
98%