73-975
Tocris Bioscience™ MS 39
Manufacturer: Tocris Bioscience™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 73-975-Each-of-1 | In Stock | ₹ 43,788.00 |
73-975 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,788.00
GST (18%): ₹ 7,881.84
Total Price: ₹ 51,669.84
Chemical Name or Material
(2 S,4 R)-1-(-2-(11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Target
Active Degraders
Purity
0.98
Quantity
5 mg
Molecular Formula
C55H71ClFN9O7S
Related Products
Description
- MS 39 is a potent, high affinity and selective Degrader (PROTAC™) of mutant epidermal growth factor receptor (EGFR), comprising gefitinib (Iressa, Cat
- No
- 3000) conjugated via a linker to a VHL ligand
- MS 39 potently induces degradation of mutant EGFR (DC50 values are 5 nM and 3.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) lung cancer cell lines, respectively), but exhibits no significant effect in cell lines bearing wild-type EGFR at concentrations up to 10 μM
- MS 39 inhibits proliferation of H3255 lung cancer cells in vitro , and is bioavailable in mice following ip administration
- PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: (2 S,4 R)-1-(-2-(11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Target: Active Degraders
Purity: 0.98
Quantity: 5 mg
Molecular Formula: C55H71ClFN9O7S
Chemical Name or Material:
(2 S,4 R)-1-(-2-(11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Target:
Active Degraders
Purity:
0.98
Quantity:
5 mg
Molecular Formula:
C55H71ClFN9O7S
Chemical Name or Material: (2 R,4 S)-1-(-2-(11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Target: Active Degrader Negative Controls
Purity: 0.98
Quantity: 5 mg
Molecular Formula: C55H71ClFN9O7S
Chemical Name or Material:
(2 R,4 S)-1-(-2-(11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Target:
Active Degrader Negative Controls
Purity:
0.98
Quantity:
5 mg
Molecular Formula:
C55H71ClFN9O7S
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