74-202
Tocris Bioscience™ LC 2
Manufacturer: Tocris Bioscience™
CAS Number: 2502156-03-6
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 74-202-Each-of-1 | In Stock | ₹ 62,033.00 |
74-202 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 62,033.00
GST (18%): ₹ 11,165.94
Total Price: ₹ 73,198.94
Chemical Name or Material
(2 S,4 R)-1-(-2-(3-(3-(-2-(((7-(8-Chloronaphthalen-1-yl)-4-(-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-m)
Quantity
2 mg
Molecular Formula
C59H71ClFN11O7S
CAS
2502156-03-6
Target
Active Degraders
Purity
0.95
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Medchemexpress LLC HY-137516 25mg , LC-2 CAS:2502156-03-6 Purity:>98% | Medchemexpress LLC | ₹ 3,08,385.00 | |
| | Medchemexpress LLC HY-137516 5mg , LC-2 CAS:2502156-03-6 Purity:>98% | Medchemexpress LLC | ₹ 91,581.00 | |
 | eMolecules Broadpharm / LC-2 / 1mg / 718092065 / BP-28378 / 95.000 / 2502156-03-6 / [null] / 1132.800 / C59H71ClFN11O7S | eMolecules | ₹ 15,720.96 | |
 | LC-2 | ChemScene | ₹ 12,727.00 - ₹ 1,02,973.00 | |
 | 2502156-03-6 | (2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-m | A2B Chem | ₹ 9,167.00 - ₹ 1,16,234.00 |
Related Products
Description
- LC 2 is a mutant-selective PROTAC™ Degrader of KRAS, comprising a ligand for the von Hippel Lindau E3 ligase joined to the KRAS inhibitor MRTX849
- LC 2 induces selective degradation of KRASG12C in cancer cell lines without inducing degradation of any other mutants (DC50 = 0.25-0.76 μM), leading to suppression of MAPK signaling and modulation of ERK signaling in both homozygous and heterozygous KRASG12C cancer cell lines
- LC 2 inhibits phosphorylation of ERK in SW1573 cell lines
- Negative control LC 2 Epimer (Cat
- No
- 7421) also available
- PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: (2 S,4 R)-1-(-2-(3-(3-(-2-(((7-(8-Chloronaphthalen-1-yl)-4-(-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-m)
Quantity: 2 mg
Molecular Formula: C59H71ClFN11O7S
CAS: 2502156-03-6
Target: Active Degraders
Purity: 0.95
Chemical Name or Material:
(2 S,4 R)-1-(-2-(3-(3-(-2-(((7-(8-Chloronaphthalen-1-yl)-4-(-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-m)
Quantity:
2 mg
Molecular Formula:
C59H71ClFN11O7S
CAS:
2502156-03-6
Target:
Active Degraders
Purity:
0.95
Chemical Name or Material: 6-[[4-(1 H-Indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3 H)-benzoxazolone
Quantity: 10 mg
Molecular Formula: C20H18N4O5S
CAS: 2567914-01-4
Target: Hydrolase Inhibitors
Purity: 0.95
Chemical Name or Material:
6-[[4-(1 H-Indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3 H)-benzoxazolone
Quantity:
10 mg
Molecular Formula:
C20H18N4O5S
CAS:
2567914-01-4
Target:
Hydrolase Inhibitors
Purity:
0.95
Chemical Name or Material: 6-[[4-(1 H-Indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3 H)-benzoxazolone
Quantity: 50 mg
Molecular Formula: C20H18N4O5S
CAS: 2567914-01-4
Target: Hydrolase Inhibitors
Purity: 0.95
Chemical Name or Material:
6-[[4-(1 H-Indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3 H)-benzoxazolone
Quantity:
50 mg
Molecular Formula:
C20H18N4O5S
CAS:
2567914-01-4
Target:
Hydrolase Inhibitors
Purity:
0.95
Chemical Name or Material: __
Quantity: 25 KU
Molecular Formula: __
CAS: __
Target: __
Purity: __
Chemical Name or Material:
__
Quantity:
25 KU
Molecular Formula:
__
CAS:
__
Target:
__
Purity:
__