74-635
Tocris Bioscience™ SJF 0628
Manufacturer: Tocris Bioscience™
CAS Number: 2413035-41-1
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 74-635-Each-of-1 | In Stock | ₹ 35,592.96 |
74-635 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,592.96
GST (18%): ₹ 6,406.733
Total Price: ₹ 41,999.693
Chemical Name or Material
(2 S,4 R)-1-(-2-(2-(4-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1 H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Quantity
5 mg
Molecular Formula
C51H57F2N9O7S2
CAS
2413035-41-1
Target
Active Degraders
Purity
0.98
Other Options
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Description
- SJF 0628 is a potent, high affinity and mutant-selective Degrader (PROTAC™) of BRAF, comprising a ligand for the von Hippel Lindau E3 ligase joined by a piperazine linker to the BRAF kinase inhibitor vemurafenib
- SJF 0628 induces degradation of all 3 classes of BRAF mutant in BRAF-dependent cancer cells without inducing degradation of the BRAFWT protein
- The product degrades mutant BRAFV600E in BRAF-driven cancer cell lines (DC50 = 6.8 nM - 28 nM)
- SJ 0628 inhibits phosphorylation of MEK and ERK in SK-MEL-28 cells (DC50 = 10 nM) and inhibits cell growth in mutant-BRAF driven cancer cells (EC50 = 37 nM)
- SJF 0661 negative control (Cat
- No
- 7464) also available
- PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: (2 S,4 R)-1-(-2-(2-(4-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1 H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Quantity: 5 mg
Molecular Formula: C51H57F2N9O7S2
CAS: 2413035-41-1
Target: Active Degraders
Purity: 0.98
Chemical Name or Material:
(2 S,4 R)-1-(-2-(2-(4-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1 H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Quantity:
5 mg
Molecular Formula:
C51H57F2N9O7S2
CAS:
2413035-41-1
Target:
Active Degraders
Purity:
0.98
Chemical Name or Material: 2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-6-[4-(4-piperidinylmethyl)-1-piperazinyl]-1 H-isoindole-1,3(2 H)-dione dihydrochloride
Quantity: 25 mg
Molecular Formula: C23H28FN5O40.2 HCl
CAS: __
Target: Degrader Building Blocks
Purity: 0.95
Chemical Name or Material:
2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-6-[4-(4-piperidinylmethyl)-1-piperazinyl]-1 H-isoindole-1,3(2 H)-dione dihydrochloride
Quantity:
25 mg
Molecular Formula:
C23H28FN5O40.2 HCl
CAS:
__
Target:
Degrader Building Blocks
Purity:
0.95
Chemical Name or Material: 3-[1,3-Dihydro-1-oxo-5-[4-(4-piperidinylmethyl)-1-piperazinyl]-2 H-isoindol-2-yl]-2,6-piperidinedione dihydrochloride
Quantity: 25 mg
Molecular Formula: C23H31N5O30.2 HCl
CAS: 2520105-60-4
Target: Degrader Building Blocks
Purity: 0.95
Chemical Name or Material:
3-[1,3-Dihydro-1-oxo-5-[4-(4-piperidinylmethyl)-1-piperazinyl]-2 H-isoindol-2-yl]-2,6-piperidinedione dihydrochloride
Quantity:
25 mg
Molecular Formula:
C23H31N5O30.2 HCl
CAS:
2520105-60-4
Target:
Degrader Building Blocks
Purity:
0.95
Chemical Name or Material: 2-[(2-Azidoacetyl)amino]-2-deoxy-D-mannopyranose-1,3,4,6-tetraacetate
Quantity: 10 mg
Molecular Formula: C16H22N4O10
CAS: 361154-30-5
Target: Photoactivatable Cross-linking Probes
Purity: 0.95
Chemical Name or Material:
2-[(2-Azidoacetyl)amino]-2-deoxy-D-mannopyranose-1,3,4,6-tetraacetate
Quantity:
10 mg
Molecular Formula:
C16H22N4O10
CAS:
361154-30-5
Target:
Photoactivatable Cross-linking Probes
Purity:
0.95