78-165
Tocris Bioscience™ UNC 6852
Manufacturer: Tocris Bioscience™
CAS Number: 2688842-08-0
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 78-165-Each-of-1 | In Stock | ₹ 19,678.80 |
78-165 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 19,678.80
GST (18%): ₹ 3,542.184
Total Price: ₹ 23,220.984
Chemical Name or Material
(2 S,4 R)-1-(-2-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4 ]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Quantity
5 mg
Molecular Formula
C43H48N10O6S
CAS
2688842-08-0
Target
Active Degraders
Purity
0.98
Related Products
Description
- UNC 6852 is a polycomb repressive complex 2 (PRC2) Degrader (PROTAC™; DC50 = 0.79 μM)
- It comprises an EED (embryonic ectoderm development) based ligand, joined by a linker to a von Hippel-Lindau ligand
- In B lymphoblast cell lines, UNC 6852 selectively degrades PRC2 components EED (DC50 = 0.31 μM, Dmax = 94%), enhancer of zeste homolog 2 (EZH2, DC50 = 0.67 μM, Dmax = 96%), and suppressor of zeste homolog 12 (SUZ12, DC50 = 0.59 μM, Dmax = 82%)
- In zebrafish, UNC 6852 treatment increases transcription of tfpia and prolongs time to occlusion (TTO) in the caudal vein following laser injury
- PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: (2 S,4 R)-1-(-2-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4 ]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Quantity: 5 mg
Molecular Formula: C43H48N10O6S
CAS: 2688842-08-0
Target: Active Degraders
Purity: 0.98
Chemical Name or Material:
(2 S,4 R)-1-(-2-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4 ]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Quantity:
5 mg
Molecular Formula:
C43H48N10O6S
CAS:
2688842-08-0
Target:
Active Degraders
Purity:
0.98
Chemical Name or Material: (2 S,4 R)-4-Hydroxy-1-(-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-(-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Quantity: 5 mg
Molecular Formula: C50H59F3N10O6S
CAS: 2743427-26-9
Target: Active Degraders
Purity: 0.98
Chemical Name or Material:
(2 S,4 R)-4-Hydroxy-1-(-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-(-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Quantity:
5 mg
Molecular Formula:
C50H59F3N10O6S
CAS:
2743427-26-9
Target:
Active Degraders
Purity:
0.98
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