78-185
Tocris Bioscience™ GSK 215
Manufacturer: Tocris Bioscience™
CAS Number: 2743427-26-9
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 78-185-Each-of-1 | In Stock | ₹ 37,780.50 |
78-185 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,780.50
GST (18%): ₹ 6,800.49
Total Price: ₹ 44,580.99
Chemical Name or Material
(2 S,4 R)-4-Hydroxy-1-(-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-(-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Quantity
5 mg
Molecular Formula
C50H59F3N10O6S
CAS
2743427-26-9
Target
Active Degraders
Purity
0.98
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Medchemexpress LLC HY-132296 5mg , GSK215 CAS:2743427-26-9 Purity:>98% | Medchemexpress LLC | ₹ 35,884.80 |
Related Products
Description
- GSK 215 is a potent and selective focal adhesion kinase (FAK) Degrader (PROTAC™; pDC50 = 8.4, last for 96 h)
- Comprises the FAK inhibitor, PND 1186 (Cat
- No
- 6891), joined by a linker to a VHL E3 ligase ligand
- Kinome binding (KinoBead profiling) shows GSK 215 (at 10 nM) has high selectivity for the FAK kinase domain
- GSK 215 inhibits cell proliferation in MCF-7 and A549 cells and suppresses A549 cell motility in a wound scratch model system
- In CD1 mice, GSK 215 injection induces rapid and profound degradation of FAK in liver (Dmax = 85% at 18h).
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: (2 S,4 R)-4-Hydroxy-1-(-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-(-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Quantity: 5 mg
Molecular Formula: C50H59F3N10O6S
CAS: 2743427-26-9
Target: Active Degraders
Purity: 0.98
Chemical Name or Material:
(2 S,4 R)-4-Hydroxy-1-(-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-(-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Quantity:
5 mg
Molecular Formula:
C50H59F3N10O6S
CAS:
2743427-26-9
Target:
Active Degraders
Purity:
0.98
Chemical Name or Material: __
Quantity: 100 Tests
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