74-325
Tocris Bioscience™ SIM1
Manufacturer: Tocris Bioscience™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 74-325-Each-of-1 | In Stock | ₹ 42,364.00 |
74-325 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,364.00
GST (18%): ₹ 7,625.52
Total Price: ₹ 49,989.52
Chemical Name or Material
N,N'-(11-((2-((-1-((2 S,4 R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)methyl)-11-methyl-3,6,9,13,16,19-hexaoxahenicosane-1,21-diyl)bis(2-(-4-(4-chlorophenyl)-2,3,9-tri
Target
Active Degraders
Purity
0.98
Quantity
5 mg
Molecular Formula
C79H98Cl2N14O13S3
Related Products
Description
- SIM1 is a potent and selective trivalent PROTAC™ Degrader based on BET bromodomain inhibitors linked to a Von Hippel Lindau (VHL) ligand via branched linkers
- SIM1 degrades all BET family proteins with a preference for BRD2 (DC50 values = 0.7 nM, 1.1 nM and 3.3 nM for BRD4, BRD2 and BRD3, respectively)
- SIM1 degrades BRD2 more significantly and rapidly than BRD3 and BRD4, and degrades BET proteins with a higher potency than a bivalent degrader
- SIM1 also decreases protein levels for Myc and HMOX1 and induces apoptosis in prostate cancer cells.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: N,N'-(11-((2-((-1-((2 S,4 R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)methyl)-11-methyl-3,6,9,13,16,19-hexaoxahenicosane-1,21-diyl)bis(2-(-4-(4-chlorophenyl)-2,3,9-tri
Target: Active Degraders
Purity: 0.98
Quantity: 5 mg
Molecular Formula: C79H98Cl2N14O13S3
Chemical Name or Material:
N,N'-(11-((2-((-1-((2 S,4 R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)methyl)-11-methyl-3,6,9,13,16,19-hexaoxahenicosane-1,21-diyl)bis(2-(-4-(4-chlorophenyl)-2,3,9-tri
Target:
Active Degraders
Purity:
0.98
Quantity:
5 mg
Molecular Formula:
C79H98Cl2N14O13S3
Chemical Name or Material: 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1 H-isoindole-1,3(2 H)-dione
Target: Degrader Building Blocks
Purity: 0.95
Quantity: 25 mg
Molecular Formula: C17H18N6O5
Chemical Name or Material:
4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1 H-isoindole-1,3(2 H)-dione
Target:
Degrader Building Blocks
Purity:
0.95
Quantity:
25 mg
Molecular Formula:
C17H18N6O5
Chemical Name or Material: 4-[[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1 H-isoindole-1,3(2 H)-dione
Target: Degrader Building Blocks
Purity: 0.95
Quantity: 25 mg
Molecular Formula: C21H26N6O7
Chemical Name or Material:
4-[[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1 H-isoindole-1,3(2 H)-dione
Target:
Degrader Building Blocks
Purity:
0.95
Quantity:
25 mg
Molecular Formula:
C21H26N6O7
Chemical Name or Material: 4-[(14-Azido-3,6,9,12-tetraoxatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)-1 H-isoindole-1,3(2 H)-dione
Target: Degrader Building Blocks
Purity: 0.95
Quantity: 25 mg
Molecular Formula: C23H30N6O8
Chemical Name or Material:
4-[(14-Azido-3,6,9,12-tetraoxatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)-1 H-isoindole-1,3(2 H)-dione
Target:
Degrader Building Blocks
Purity:
0.95
Quantity:
25 mg
Molecular Formula:
C23H30N6O8